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https://hdl.handle.net/2440/117364
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Type: | Journal article |
Title: | Physiological functions of nedd4-2: lessons from knockout mouse models |
Author: | Manning, J.A. Kumar, S. |
Citation: | Trends in Biochemical Sciences, 2018; 43(8):635-647 |
Publisher: | Elsevier |
Issue Date: | 2018 |
ISSN: | 0968-0004 1362-4326 |
Statement of Responsibility: | Jantina A. Manning, Sharad Kumar |
Abstract: | Protein modification by ubiquitination plays a key evolutionarily conserved role in regulating membrane proteins. Nedd4-2, a ubiquitin ligase, targets membrane proteins such as ion channels and transporters for ubiquitination. This Nedd4-2-mediated ubiquitination provides a crucial step in controlling the membrane availability of these proteins, thus affecting their signaling and physiological outcomes. In one well-studied example, Nedd4-2 fine-tunes the physiological function of the epithelial sodium channel (ENaC), thus modulating Na+ reabsorption by epithelia to maintain whole-body Na+ homeostasis. This review summarizes the key signaling pathways regulated by Nedd4-2 and the possible implications of such regulation in various pathologies. |
Keywords: | ENaC Nedd4-2 ion channels pathophysiology sodium ubiquitination |
Rights: | © 2018 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.tibs.2018.06.004 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1103006 http://purl.org/au-research/grants/nhmrc/1020755 http://purl.org/au-research/grants/nhmrc/1099307 |
Published version: | http://dx.doi.org/10.1016/j.tibs.2018.06.004 |
Appears in Collections: | Aurora harvest 8 Chemistry publications |
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