Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/11772
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Fetal hypothalamus-pituitary-adrenal axis on the road to parturition |
Author: | Schwartz, Jeffrey McMillen, Isabella Caroline |
Citation: | Clinical and Experimental Pharmacology and Physiology, 2001; 28 (1-2):108-112 |
Publisher: | Blackwell |
Issue Date: | 2001 |
ISSN: | 0305-1870 |
School/Discipline: | School of Molecular and Biomedical Science |
Statement of Responsibility: | Jeff Schwartz and I Caroline McMillen |
Abstract: | 1. Activity of the fetal hypothalamus–pituitary–adrenal (HPA) axis waxes and wanes as a function of gestational age. 2. In a number of species, including sheep, at the end of gestation there is an increase in HPA activity, as characterized by an increase in fetal plasma glucocorticoids. 3. To a certain degree, the hypothalamus, pituitary and adrenal all act autonomously and, therefore, may be thought of as contributing to the initiation of the signal that results in the increase in steroidogenesis before birth. 4. Because it integrates sensory information from beyond as well as within the HPA axis and likely triggers developmental changes within the pituitary, the hypothalamus may be a ‘first among equals’ in being the ultimate source of triggering information for the HPA axis. |
Description: | The definitive version is available at www.blackwell-synergy.com |
DOI: | 10.1046/j.1440-1681.2001.03412.x |
Appears in Collections: | Physiology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.