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|Title:||Responsive upconversion nanoprobe for background-free hypochlorous acid detection and bioimaging|
|Citation:||Small, 2019; 15(2):1803712-1-1803712-11|
|Run Zhang, Liuen Liang, Qingtao Meng, Jiangbo Zhao, Hang T. Ta, Li Li, Zhiqiang Zhang, Yasmina Sultanbawa and Zhi Ping Xu|
|Abstract:||Responsive nanoprobes play an important role in bioassay and bioimaging, early diagnosis of diseases and treatment monitoring. Herein, a upconversional nanoparticle (UCNP)-based nanoprobe, Ru@UCNPs, for specific sensing and imaging of hypochlorous acid (HOCl) is reported. This Ru@UCNP nanoprobe consists of two functional components,, i.e., NaYF₄ :Yb, Tm UCNPs that can convert near infrared light-to-visible light as the energy donor, and a HOCl-responsive ruthenium(II) complex [Ru(bpy)₂ (DNCH-bpy)](PF₆)₂ (Ru-DNPH) as the energy acceptor and also the upconversion luminescence (UCL) quencher. Within this luminescence resonance energy transfer nanoprobe system, the UCL OFF-ON emission is triggered specifically by HOCl. This triggering reaction enables the detection of HOCl in aqueous solution and biological systems. As an example of applications, the Ru@UCNPs nanoprobe is loaded onto test papers for semiquantitative HOCl detection without any interference from the background fluorescence. The application of Ru@UCNPs for background-free detection and visualization of HOCl in cells and mice is successfully demonstrated. This research has thus shown that Ru@UCNPs is a selective HOCl-responsive nanoprobe, providing a new way to detect HOCl and a new strategy to develop novel nanoprobes for in situ detection of various biomarkers in cells and early disgnosis of animal diseases.|
|Keywords:||Bioassay and imaging; luminescence resonance energy transfer; nanoprobes; paper-based test strips; selective HOCl detection and imaging|
|Rights:||© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim|
|Appears in Collections:||IPAS publications|
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