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dc.contributor.authorZhang, R.en
dc.contributor.authorLiang, L.en
dc.contributor.authorMeng, Q.en
dc.contributor.authorZhao, J.en
dc.contributor.authorTa, H.en
dc.contributor.authorLi, L.en
dc.contributor.authorZhang, Z.en
dc.contributor.authorSultanbawa, Y.en
dc.contributor.authorXu, Z.en
dc.identifier.citationSmall, 2019; 15(2):1803712-1-1803712-11en
dc.description.abstractResponsive nanoprobes play an important role in bioassay and bioimaging, early diagnosis of diseases and treatment monitoring. Herein, a upconversional nanoparticle (UCNP)-based nanoprobe, Ru@UCNPs, for specific sensing and imaging of hypochlorous acid (HOCl) is reported. This Ru@UCNP nanoprobe consists of two functional components,, i.e., NaYF₄ :Yb, Tm UCNPs that can convert near infrared light-to-visible light as the energy donor, and a HOCl-responsive ruthenium(II) complex [Ru(bpy)₂ (DNCH-bpy)](PF₆)₂ (Ru-DNPH) as the energy acceptor and also the upconversion luminescence (UCL) quencher. Within this luminescence resonance energy transfer nanoprobe system, the UCL OFF-ON emission is triggered specifically by HOCl. This triggering reaction enables the detection of HOCl in aqueous solution and biological systems. As an example of applications, the Ru@UCNPs nanoprobe is loaded onto test papers for semiquantitative HOCl detection without any interference from the background fluorescence. The application of Ru@UCNPs for background-free detection and visualization of HOCl in cells and mice is successfully demonstrated. This research has thus shown that Ru@UCNPs is a selective HOCl-responsive nanoprobe, providing a new way to detect HOCl and a new strategy to develop novel nanoprobes for in situ detection of various biomarkers in cells and early disgnosis of animal diseases.en
dc.description.statementofresponsibilityRun Zhang, Liuen Liang, Qingtao Meng, Jiangbo Zhao, Hang T. Ta, Li Li, Zhiqiang Zhang, Yasmina Sultanbawa and Zhi Ping Xuen
dc.rights© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimen
dc.subjectBioassay and imaging; luminescence resonance energy transfer; nanoprobes; paper-based test strips; selective HOCl detection and imagingen
dc.titleResponsive upconversion nanoprobe for background-free hypochlorous acid detection and bioimagingen
dc.typeJournal articleen
pubs.library.collectionIPAS publicationsen
dc.identifier.orcidZhao, J. [0000-0002-5883-6017]en
Appears in Collections:IPAS publications

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