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Type: Journal article
Title: Biocompatibility characteristics of the metal organic framework ZIF-8 for therapeutical applications
Author: Hoop, M.
Walde, C.
Riccò, R.
Mushtaq, F.
Terzopoulou, A.
Chen, X.
deMello, A.
Doonan, C.
Falcaro, P.
Nelson, B.
Puigmartí-Luis, J.
Pané, S.
Citation: Applied Materials Today, 2018; 11:13-21
Publisher: Elsevier
Issue Date: 2018
ISSN: 2352-9407
Statement of
Marcus Hoop, Claudio F.Walde, Raffaele Riccò, Fajer Mushtaq ... Christian J.Doonan, Paolo Falcaro ... et al.
Abstract: Metal–organic frameworks (MOFs) are a class of crystalline materials constructed from organic linkers and inorganic nodes. MOFs typically possess ultra-high surface areas and pore volumes; thus, they are ideal candidates for biomedical applications. Zinc Imidazolate Framework 8 (ZIF-8) has been widely established in the literature as a potential candidate for on-demand drug delivery applications. Indeed, ZIF-8 has a remarkable loading capacity, stability in physiological environments, and tunable drug release properties. However, the use of ZIF-8 for in vivo applications requires a clear understanding of the interaction of ZIF-8 with biological tissue. In this work, we investigated the biocompatibility of ZIF-8 toward six different cell lines representing various body parts (kidney, skin, breast, blood, bones, and connective tissue). Our results suggest that ZIF-8 has no significant cytotoxicity up to a threshold value of 30 μg mL−1. Above 30 μg mL−1, the cytotoxicity is shown to result from the influence of released Zinc ions (Zn2+) on the mitochondrial ROS production. This adverse effect is responsible for cell cycle arrest in the G2/M phase due to irreversible DNA damage, ultimately initiating cellular apoptosis pathways. Due to this insight, we encapsulated a hormone, insulin, into ZIF-8 particles and then compared its drug delivery capabilities to the aforementioned cytotoxicity values. Our results suggest that ZIF-8 is suitable for therapeutic applications. Furthermore, this study establishes a clear understanding of the interaction of ZIF-8 and its constituents with various cell lines and highlights the important biocompatibility factors that must be considered for future in vivo testing.
Keywords: Metal organic framework; zeolitic imidazolate framework; ZIF-8; Zn2+; biocompatibility; biomedical applications
Rights: Metal organic framework Zeolitic imidazolate framework ZIF-8 Zn2+ Biocompatibility Biomedical applications
RMID: 0030083061
DOI: 10.1016/j.apmt.2017.12.014
Appears in Collections:Physics publications

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