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https://hdl.handle.net/2440/118157
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dc.contributor.author | Hoop, M. | - |
dc.contributor.author | Walde, C. | - |
dc.contributor.author | Riccò, R. | - |
dc.contributor.author | Mushtaq, F. | - |
dc.contributor.author | Terzopoulou, A. | - |
dc.contributor.author | Chen, X. | - |
dc.contributor.author | deMello, A. | - |
dc.contributor.author | Doonan, C. | - |
dc.contributor.author | Falcaro, P. | - |
dc.contributor.author | Nelson, B. | - |
dc.contributor.author | Puigmartí-Luis, J. | - |
dc.contributor.author | Pané, S. | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | APPLIED MATERIALS TODAY, 2018; 11:13-21 | - |
dc.identifier.issn | 2352-9407 | - |
dc.identifier.issn | 2352-9407 | - |
dc.identifier.uri | http://hdl.handle.net/2440/118157 | - |
dc.description.abstract | Metal–organic frameworks (MOFs) are a class of crystalline materials constructed from organic linkers and inorganic nodes. MOFs typically possess ultra-high surface areas and pore volumes; thus, they are ideal candidates for biomedical applications. Zinc Imidazolate Framework 8 (ZIF-8) has been widely established in the literature as a potential candidate for on-demand drug delivery applications. Indeed, ZIF-8 has a remarkable loading capacity, stability in physiological environments, and tunable drug release properties. However, the use of ZIF-8 for in vivo applications requires a clear understanding of the interaction of ZIF-8 with biological tissue. In this work, we investigated the biocompatibility of ZIF-8 toward six different cell lines representing various body parts (kidney, skin, breast, blood, bones, and connective tissue). Our results suggest that ZIF-8 has no significant cytotoxicity up to a threshold value of 30 μg mL−1. Above 30 μg mL−1, the cytotoxicity is shown to result from the influence of released Zinc ions (Zn2+) on the mitochondrial ROS production. This adverse effect is responsible for cell cycle arrest in the G2/M phase due to irreversible DNA damage, ultimately initiating cellular apoptosis pathways. Due to this insight, we encapsulated a hormone, insulin, into ZIF-8 particles and then compared its drug delivery capabilities to the aforementioned cytotoxicity values. Our results suggest that ZIF-8 is suitable for therapeutic applications. Furthermore, this study establishes a clear understanding of the interaction of ZIF-8 and its constituents with various cell lines and highlights the important biocompatibility factors that must be considered for future in vivo testing. | - |
dc.description.statementofresponsibility | Marcus Hoop, Claudio F.Walde, Raffaele Riccò, Fajer Mushtaq ... Christian J.Doonan, Paolo Falcaro ... et al. | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | Metal organic framework Zeolitic imidazolate framework ZIF-8 Zn2+ Biocompatibility Biomedical applications | - |
dc.source.uri | http://dx.doi.org/10.1016/j.apmt.2017.12.014 | - |
dc.subject | Metal organic framework; zeolitic imidazolate framework; ZIF-8; Zn2+; biocompatibility; biomedical applications | - |
dc.title | Biocompatibility characteristics of the metal organic framework ZIF-8 for therapeutical applications | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.apmt.2017.12.014 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 8 Physics publications |
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