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https://hdl.handle.net/2440/118735
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Type: | Journal article |
Title: | Associations between the cyclooxygenase-2 expression in circulating tumor cells and the clinicopathological features of patients with colorectal cancer |
Author: | Cai, J. Huang, L. Huang, J. Kang, L. Lin, H. Huang, P. Zhu, P. Wang, J. Dong, J. Wang, L. Xian, C.J. |
Citation: | Journal of Cellular Biochemistry, 2019; 120(4):4935-4941 |
Publisher: | Wiley |
Issue Date: | 2019 |
ISSN: | 0730-2312 1097-4644 |
Statement of Responsibility: | Jinlin Cai, Liang Huang, Jun Huang, Liang Kang, Hongcheng Lin ... Cory J. Xian ... et al. |
Abstract: | While previous studies have shown that the number of circulating tumor cells (CTCs) alone is not sufficient to reflect tumor progression and that cyclooxygenase-2 (COX-2) expression is correlated with colorectal cancer (CRC) metastasis, COX-2 expression status and its potential functions in CTCs of CRC patients are unknown. Here, epithelial-mesenchymal transition (EMT) phenotype-based subsets of CTCs and the COX-2 expression status in CTCs were identified and their potential clinical values were assessed in 91 CRC patients. CTCs were enumerated in peripheral blood and subsets of CTCs (epithelial [eCTCs], mesenchymal [mCTCs], and biophenotypic [bCTCs]) and the COX-2 expression status were determined using the RNA in situ hybridization method. CTCs were detected in 80.2% (73 of 91) patients. Neither the total CTC nor eCTC numbers were found to significantly associate with any of the clinicopathological features. However, the number of mCTCs was significantly associated with distance metastasis (P = 0.035) and had a trend of being associated with lymph node metastasis ( P = 0.055). Among the 73 patients enrolled for evaluating COX-2 expression, 52.5% (38 of 73) were found to express COX-2 in CTCs, and COX-2 expression in CTCs was not found to associate with the clinicopathological factors. However, COX-2 expression in mCTCs tended to have a higher rate in patients with metastasis compared with those without metastasis (72.0% vs 42.8%; P = 0.072). Furthermore, COX-2 expression and mCTC marker expression correlated positively ( R = 0.287; P = 0.017). Further studies are required to investigate the clinical value of the expression of COX-2 in mCTCs, especially in CRC patients with the advanced tumor stage and distant metastasis. |
Keywords: | COX-2 circulating tumor cells colorectal cancer epithelial-mesenchymal transition |
Rights: | © 2018 Wiley Periodicals, Inc. |
DOI: | 10.1002/jcb.27768 |
Published version: | http://dx.doi.org/10.1002/jcb.27768 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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