Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/11876
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Type: Journal article
Title: Perinatal growth and plasma GH profiles in adolescent and adult sheep
Author: Gatford, K.
Clarke, I.
De Blasio, M.
McMillen, I.
Robinson, J.
Owens, J.
Citation: Journal of Endocrinology, 2002; 173(1):151-159
Publisher: Soc Endocrinology
Issue Date: 2002
ISSN: 0022-0795
1479-6805
Statement of
Responsibility: 
K.L. Gatford, I.J. Clarke, M.J. De Blasio, I.C. McMillen, S. Robinson and J.A. Owens
Abstract: Poor prenatal growth is associated with limited evidence of GH deficiency in adult humans, which may contribute to their increased risk of cardiovascular and metabolic disease. We therefore examined the effects of placental restriction of fetal growth (PR) on size at birth, neonatal fractional growth rate (FGR) and the circulating GH profile in adolescent and young adult sheep of both sexes. Moderate or severe PR decreased birth size and increased neonatal FGR of weight, crown-rump length and abdominal circumference. In adolescent males, mean and baseline GH concentrations correlated negatively and independently with birth weight and FGR of weight, and mean GH concentrations correlated negatively with current weight. In young adult males, mean GH concentrations correlated negatively and independently with birth shoulder height and FGR of shoulder height whilst, in young adult females, these correlations were positive. This suggests that restricted fetal growth and reduced neonatal growth rate in sheep are followed by elevated circulating GH in adolescent and adult males, but GH deficiency or increased GH clearance in adult females.
Keywords: Animals; Animals, Newborn; Sheep; Body Weight; Birth Weight; Growth Hormone; Analysis of Variance; Sex Characteristics; Sexual Maturation; Female; Male
Description: Copyright © 2002 by Society for Endocrinology
RMID: 0020020698
DOI: 10.1677/joe.0.1730151
Published version: http://joe.endocrinology-journals.org/cgi/content/abstract/173/1/151
Appears in Collections:Physiology publications

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