Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/118826
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Type: Journal article
Title: Hedgehog and Wingless signaling are not essential for autophagy-dependent cell death
Author: Xu, T.
Denton, D.
Kumar, S.
Citation: Biochemical Pharmacology, 2019; 162:3-13
Publisher: Elsevier
Issue Date: 2019
ISSN: 0006-2952
1873-2968
Statement of
Responsibility: 
Tianqi Xu, Donna Denton, Sharad Kumar
Abstract: Autophagy-dependent cell death is a distinct mode of regulated cell death required in a context specific manner. One of the best validated genetic models of autophagy-dependent cell death is the removal of the Drosophila larval midgut during larval-pupal transition. We have previously shown that down-regulation of growth signaling is essential for autophagy induction and larval midgut degradation. Sustained growth signaling through Ras and PI3K blocks autophagy and consequently inhibits midgut degradation. In addition, the morphogen Dpp plays an important role in regulating the correct timing of midgut degradation. Here we explore the potential roles of Hh and Wg signaling in autophagy-dependent midgut cell death. We demonstrate that Hh and Wg signaling are not involved in the regulation of autophagy-dependent cell death. However, surprisingly we found that one key component of these pathways, the Drosophila Glycogen Synthase Kinase 3, Shaggy (Sgg), may regulate midgut cell size independent of Hh and Wg signaling.
Keywords: Autophagy; Drosophila; Hh; Programmed cell death; Sgg; Wg
Rights: © 2018 Elsevier Inc. All rights reserved.
RMID: 0030106010
DOI: 10.1016/j.bcp.2018.10.027
Grant ID: http://purl.org/au-research/grants/nhmrc/1041807
http://purl.org/au-research/grants/nhmrc/1124490
http://purl.org/au-research/grants/arc/DP170100623
Appears in Collections:Pharmacology publications

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