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https://hdl.handle.net/2440/118900
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dc.contributor.author | Roughead, E.E. | - |
dc.contributor.author | Chan, E.W. | - |
dc.contributor.author | Choi, N.K. | - |
dc.contributor.author | Griffiths, J. | - |
dc.contributor.author | Jin, X.M. | - |
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Kimura, M. | - |
dc.contributor.author | Kimura, T. | - |
dc.contributor.author | Kubota, K. | - |
dc.contributor.author | Lai, E.C.C. | - |
dc.contributor.author | Man, K.K.C. | - |
dc.contributor.author | Nguyen, T.A. | - |
dc.contributor.author | Ooba, N. | - |
dc.contributor.author | Park, B.J. | - |
dc.contributor.author | Sato, T. | - |
dc.contributor.author | Shin, J.Y. | - |
dc.contributor.author | Wang, T.T. | - |
dc.contributor.author | Wong, I.C.K. | - |
dc.contributor.author | Yang, Y.H.K. | - |
dc.contributor.author | Pratt, N.L. | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Expert Opinion on Drug Safety, 2016; 15(12):1589-1595 | - |
dc.identifier.issn | 1474-0338 | - |
dc.identifier.issn | 1744-764X | - |
dc.identifier.uri | http://hdl.handle.net/2440/118900 | - |
dc.description.abstract | Objective: To determine the association between incident proton pump inhibitor (PPI) use and Clostridium difficile infections across multiple countries Method: National data covering the total population in Australia and Korea, the Canadian population over 65 years and a 3 million person random sample data set from Taiwan were assessed, as were data from a worker insurance population and a hospital inpatient/outpatient population in Japan. Sequence symmetry analysis was used to assess the association with oral vancomycin dispensing as the outcome of interest. Results: 54,957 patients were included. Positive associations were observed in Australia; adjusted sequence ratio (ASR) 2.48 (95% CI 1.90, 3.12), Korea ASR 2.15 (95%CI 2.11, 2.19), Canada ASR 1.45 (95% CI 1.16, 1.79), Japan hospital dataset ASR 3.21 (95%CI 2.12, 4.55) and Japan worker insurance dataset ASR 5.40 (95% CI 2.73, 8.75). The pooled result was ASR 2.40 (95%CI 1.88, 3.05) and 3.16 (95%CI 1.95, 5.10) when limited to Japan, Korean and Taiwan. Results did not vary by individual PPI. The temporal analysis showed effects within the first two weeks of PPI initiation. Conclusion: Our study confirms the association between PPI initiation and C. difficile infections across countries in the Asia-Pacific region. | - |
dc.description.statementofresponsibility | Elizabeth E Roughead, Esther W Chan, Nam-Kyong Choi, Jenna Griffiths, Xue-Mei Jin ... Nicole L Pratt ... et al. | - |
dc.language.iso | en | - |
dc.publisher | Taylor & Francis | - |
dc.rights | © 2016 Informa UK Limited, trading as Taylor & Francis Group | - |
dc.source.uri | http://dx.doi.org/10.1080/14740338.2016.1238071 | - |
dc.subject | Proton pump inhibitors; Clostridium difficile; adverse event; Asia; sequence symmetry analysis | - |
dc.title | Proton pump inhibitors and risk of Clostridium difficile infection: a multi-country study using sequence symmetry analysis | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1080/14740338.2016.1238071 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1040938 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1035889 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1110139 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Pratt, N.L. [0000-0001-8730-8910] | - |
Appears in Collections: | Aurora harvest 8 Pharmacology publications |
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