Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/119002
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Type: | Journal article |
Title: | A simple genetic basis of adaptation to a novel thermal environment results in complex metabolic rewiring in Drosophila |
Author: | Mallard, F. Nolte, V. Tobler, R. Kapun, M. Schlötterer, C. |
Citation: | Genome Biology, 2018; 19(1):119-1-119-15 |
Publisher: | BMC |
Issue Date: | 2018 |
ISSN: | 1474-7596 1474-760X |
Statement of Responsibility: | François Mallard, Viola Nolte, Ray Tobler, Martin Kapun and Christian Schlötterer |
Abstract: | BACKGROUND:Population genetic theory predicts that rapid adaptation is largely driven by complex traits encoded by many loci of small effect. Because large-effect loci are quickly fixed in natural populations, they should not contribute much to rapid adaptation. RESULTS:To investigate the genetic architecture of thermal adaptation - a highly complex trait - we performed experimental evolution on a natural Drosophila simulans population. Transcriptome and respiration measurements reveal extensive metabolic rewiring after only approximately 60 generations in a hot environment. Analysis of genome-wide polymorphisms identifies two interacting selection targets, Sestrin and SNF4Aγ, pointing to AMPK, a central metabolic switch, as a key factor for thermal adaptation. CONCLUSIONS:Our results demonstrate that large-effect loci segregating at intermediate allele frequencies can allow natural populations to rapidly respond to selection. Because SNF4Aγ also exhibits clinal variation in various Drosophila species, we suggest that this large-effect polymorphism is maintained by temporal and spatial temperature variation in natural environments. |
Keywords: | Experimental evolution; evolve and resequence; thermal adaptation; Pool-Seq; RNASeq |
Rights: | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
DOI: | 10.1186/s13059-018-1503-4 |
Published version: | http://dx.doi.org/10.1186/s13059-018-1503-4 |
Appears in Collections: | Aurora harvest 8 Environment Institute publications |
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hdl_119002.pdf | Published version | 1.45 MB | Adobe PDF | View/Open |
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