Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/119015
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Type: Journal article
Title: Characterisation of major histocompatibility complex class I transcripts in an Australian dragon lizard
Author: Hacking, J.
Bertozzi, T.
Moussalli, A.
Bradford, T.
Gardner, M.
Citation: Developmental and Comparative Immunology, 2018; 84:164-171
Publisher: Elsevier
Issue Date: 2018
ISSN: 0145-305X
1879-0089
Statement of
Responsibility: 
Jessica Hacking, Terry Bertozzi, Adnan Moussalli, Tessa Bradford, Michael Gardner
Abstract: Characterisation of squamate major histocompatibility complex (MHC) genes has lagged behind other taxonomic groups. MHC genes encode cell-surface glycoproteins that present self- and pathogen-derived peptides to T cells and play a critical role in pathogen recognition. Here we characterise MHC class I transcripts for an agamid lizard (Ctenophorus decresii) and investigate the evolution of MHC class I in Iguanian lizards. An iterative assembly strategy was used to identify six full-length C. decresii MHC class I transcripts, which were validated as likely to encode classical class I MHC molecules. Evidence for exon shuffling recombination was uncovered for C. decresii transcripts and Bayesian phylogenetic analysis of Iguanian MHC class I sequences revealed a pattern expected under a birth-and-death mode of evolution. This work provides a stepping stone towards further research on the agamid MHC class I region.
Keywords: Transcriptome assembly; Iguania; Agamidae; Ctenophorus decresii; MHC class I evolution
Rights: © 2018 Elsevier Ltd. All rights reserved.
RMID: 0030083165
DOI: 10.1016/j.dci.2018.02.012
Appears in Collections:Ecology, Evolution and Landscape Science publications

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