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https://hdl.handle.net/2440/11902
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DC Field | Value | Language |
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dc.contributor.author | Sullivan, Lucy C. | en |
dc.contributor.author | Daniels, Christopher Brian | en |
dc.contributor.author | Phillips, Ian D. | en |
dc.contributor.author | Orgeig, Sandra | en |
dc.contributor.author | Whitsett, Jeffrey A. | en |
dc.date.issued | 1998 | en |
dc.identifier.citation | Journal of Molecular Evolution, 1998; 46(46):131-138 | en |
dc.identifier.issn | 0022-2844 | en |
dc.identifier.uri | http://hdl.handle.net/2440/11902 | - |
dc.description.abstract | Surface tension is reduced at the air–liquid interface in the lung by a mixture of lipids and proteins termed pulmonary surfactant. This study is the first to provide evidence for the presence of a surfactant-specific protein (Surfactant Protein A—SP-A) in the gas-holding structures of representatives of all the major vertebrate groups. Western blot analysis demonstrated cross-reactivity between an antihuman SP-A antibody and material lavaged from lungs or swimbladders of members from all vertebrate groups. Immunocytochemistry localized this SP-A–like protein to the air spaces of lungs from the actinopterygiian fish and lungfish. Northern blot analysis indicated that regions of the mouse SP-A cDNA sequence are complementary to lung mRNA from all species examined. The presence of an SP-A–like protein and SP-A mRNA in members of all the major vertebrate groups implies that the surfactant system had a single evolutionary origin in the vertebrates. Moreover, the evolution of the surfactant system must have been a prerequisite for the evolution of airbreathing. The presence of SP-A in the goldfish swimbladder demonstrates a role for the surfactant system in an organ that is no longer used for airbreathing. | en |
dc.description.statementofresponsibility | Lucy C. Sullivan, Christopher B. Daniels, Ian D. Phillips, Sandra Orgeig, Jeffrey A. Whitsett | en |
dc.language.iso | en | en |
dc.subject | Pulmonary surfactant; Surfactant protein A; Evolution; Vertebrate; Airbreathing; Surface tension | en |
dc.title | Conservation of surfactant protein a: evidence for a single origin for vertebrate pulmonary surfactant | en |
dc.type | Journal article | en |
dc.identifier.doi | 10.1007/PL00006287 | en |
Appears in Collections: | Physiology publications |
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