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|Title:||Differential effects of placental restriction on IDF-II, ACTH receptor and steroidogenic enzyme mRNA levels in the foetal sheep adrenal|
|Citation:||Journal of Neuroendocrinology, 2000; 12(1):79-85|
|Publisher:||Blackwell Science Ltd|
|Abstract:||We have investigated the effects of restriction of placental growth on foetal adrenal growth and adrenal expression of mRNAs for Insulin-like Growth Factor II (IGF-II), the IGF binding protein IGFBP-2, Steroidogenic Factor 1 (SF-1) and adrenocorticotrophic hormone (ACTH) receptor (ACTH-R) and the steroidogenic cytochrome P-450 enzymes: cholesterol side chain cleavage (CYP11A1), 17alpha-hydroxylase (CYP17) and 21-hydroxylase (CYP21A1); and 3beta-hydroxysteroid dehydrogenase/Delta5Delta4 isomerase (3betaHSD). Endometrial caruncles were removed from non-pregnant ewes before mating (placental restriction group; PR). The total adrenal: foetal weight ratio was higher in PR (n=6 foetuses) than in control foetuses (n=6 foetuses). There was no difference in plasma ACTH concentrations between the PR and control foetuses between 130 and 140 days gestation. Adrenal IGF-II mRNA levels were lower (P<0.05) in the PR group, however, adrenal IGFBP-2 mRNA levels were not different between the PR and control groups. Adrenal ACTH-R mRNA levels were also lower whilst CYP11A1 mRNA levels were increased (P<0.005) in the PR group. We conclude that foetal adrenal growth and steroidogenesis are stimulated as a consequence of foetal growth restriction and that factors other than ACTH are important in foetal adrenal activation during chronic, sustained hypoxaemia.|
|Keywords:||Adrenal Glands; Fetus; Placenta; Animals; Sheep; Multienzyme Complexes; Cytochrome P-450 Enzyme System; Cholesterol Side-Chain Cleavage Enzyme; Steroid 17-alpha-Hydroxylase; Steroid 21-Hydroxylase; Steroid Isomerases; Progesterone Reductase; Insulin-Like Growth Factor II; Receptors, Corticotropin; RNA, Messenger; Organ Size; Transcription, Genetic; Pregnancy; Reference Values; Female|
|Appears in Collections:||Physiology publications|
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