Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/119216
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dc.contributor.authorAndraweera, P.en
dc.contributor.authorLassi, Z.en
dc.date.issued2019en
dc.identifier.citationJournal of Pediatrics, 2019; 208:104-113en
dc.identifier.issn0022-3476en
dc.identifier.issn1097-6833en
dc.identifier.urihttp://hdl.handle.net/2440/119216-
dc.description.abstractOBJECTIVE:To evaluate evidence for increased cardiovascular disease (CVD) risk factors in children exposed to preeclampsia in utero. STUDY DESIGN:PubMed, the Cumulative Index to Nursing and Allied Health Literature, the Cochrane Library, and EMBASE electronic databases were searched with an end of search date of June 4, 2018. Prospective and retrospective studies that compared CVD risk factors in those exposed to preeclampsia in utero with controls were eligible. Information was extracted on established CVD risk factors, including blood pressure, lipid profile, blood glucose, fasting insulin, body mass index, and endothelial/microvascular function. RESULTS:Thirty-six studies provided cumulated data on 53 029 individuals. In utero exposure to preeclampsia was associated with 5.17 mm Hg (95% CI 1.60-8.73) greater mean systolic, 4.06 mm Hg (95% CI 0.67-7.44) greater mean diastolic blood pressure, and 0.36 kg/m2 (95% CI 0.04-0.68) greater mean body mass index during childhood or young adulthood. No significant association was seen between exposure to preeclampsia in utero and other CVD risk factors. CONCLUSIONS:Offspring of preeclamptic pregnancies demonstrate risk factors for CVD during childhood and young adult life. Early blood pressure screening of children born after preeclamptic pregnancies may identify those that require interventions or preventive strategies to reduce later life CVD risk.en
dc.description.statementofresponsibilityPrabha H. Andraweera, Zohra S. Lassien
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2019 Elsevier Inc. All rights reserved.en
dc.subjectcardiovascular risk; offspring; preeclampsia; systematic reviewen
dc.titleCardiovascular risk factors in offspring of preeclamptic pregnancies—systematic review and meta-analysisen
dc.typeJournal articleen
dc.identifier.rmid0030111698en
dc.identifier.doi10.1016/j.jpeds.2018.12.008en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1090778en
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1141382en
dc.identifier.pubid465572-
pubs.library.collectionPaediatrics publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidLassi, Z. [0000-0002-5350-6334]en
Appears in Collections:Paediatrics publications

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