Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/119237
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Postnatal corticosteroids and neurodevelopmental outcomes in extremely low birthweight or extremely preterm infants: 15-year experience in Victoria, Australia |
Author: | Cheong, J.L. Anderson, P. Roberts, G. Duff, J. Doyle, L.W. |
Citation: | Archives of Disease in Childhood: Fetal and Neonatal Edition, 2013; 98(1):F32-F36 |
Publisher: | BMJ Publishing Group |
Issue Date: | 2013 |
ISSN: | 1359-2998 1468-2052 |
Statement of Responsibility: | Jeanie Ling Cheong, Peter Anderson, Gehan Roberts, Julianne Duff, Lex W Doyle, Victorian Infant Collaborative Study Group |
Abstract: | Objective: Postnatal corticosteroids (PCS) are used to prevent or treat bronchopulmonary dysplasia (BPD) in extremely low birthweight (ELBW; <1000 g) or extremely preterm (EPT; <28 weeks) infants. In the early 2000s, concerns were raised about increased risks of cerebral palsy (CP) in association with PCS, which may have affected prescribing of PCS, and influenced rates of BPD, mortality or long-term neurosensory morbidity. Our aim was to determine the changes over time in the rates of PCS use and 2-year outcomes in ELBW/EPT infants in Victoria, Australia. Design: All ELBW or EPT infants born in Victoria, Australia in three distinct eras (1991–92, 1997 and 2005) who were alive at 7 days were included. Rates of PCS use, rates of BPD (oxygen dependency at 36 weeks' corrected age), death before 2 years of age, CP and major disability (any of moderate/severe CP, developmental quotient <−2 SD, blindness or deafness) were contrasted between cohorts. Results: The rate of PCS use and the dose prescribed diminished significantly in 2005 compared with earlier eras, but the rate of BPD rose. Non-significant changes in the rates of mortality over time were mirrored by non-significant changes in the rates of CP or major disability. Combined outcomes of mortality with either major disability or CP were similar over the three eras. Conclusions: PCS use decreased in 2005 compared with earlier eras, and was accompanied by a rise in BPD, with no significant changes in mortality or neurological morbidity. |
Keywords: | Victorian Infant Collaborative Study Group Humans Bronchopulmonary Dysplasia Adrenal Cortex Hormones Pregnancy Outcome Pregnancy Infant, Newborn Victoria Female Male Infant, Extremely Low Birth Weight Infant, Extremely Premature Practice Patterns, Physicians' |
Rights: | © 2013, BMJ Publishing Group Ltd and the Royal College of Paediatrics and Child Health |
DOI: | 10.1136/fetalneonatal-2011-301355 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1136/fetalneonatal-2011-301355 |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.