Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/119690
Type: Journal article
Title: Breast cancer susceptibility gene 1 (BRCA1) is a coactivator of the androgen receptor
Author: Park, J.
Irvine, R.
Buchanan, G.
Koh, S.
Park, J.
Tilley, W.
Stallcup, M.
Press, M.
Coetzee, G.
Citation: Cancer Research, 2000; 60(21):5946-5949
Publisher: American Association for Cancer Research
Issue Date: 2000
ISSN: 0008-5472
1538-7445
Statement of
Responsibility: 
J.J. Park, R. A. Irvine, G. Buchanan, S. S. Koh, J. M. Park ... Wayne D. Tilley ... et al.
Abstract: In the present study, the role of BRCA1 in ligand-dependent androgen receptor (AR) signaling was assessed. In transfected prostate and breast cancer cell lines, BRCA1 enhanced AR-dependent transactivation of a probasin-derived reporter gene. The effects of BRCA1 were mediated through the NH2-terminal activation function (AF-1) of the receptor. Cotransfection of p160 coactivators markedly potentiated BRCA1-mediated enhancement of AR signaling. In addition, BRCA1 was shown to interact physically with both the AR and the p160 coactivator, glucocorticoid receptor interacting protein 1. These findings suggest that BRCA1 may directly modulate AR signaling and, therefore, may have implications regarding the proliferation of normal and malignant androgen-regulated tissues.
Keywords: Prostate-cancer; proteins; domains; cells
Rights: Copyright status unknown
RMID: 0030072808
Appears in Collections:Medicine publications

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