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dc.contributor.authorPark, J.en
dc.contributor.authorIrvine, R.en
dc.contributor.authorBuchanan, G.en
dc.contributor.authorKoh, S.en
dc.contributor.authorPark, J.en
dc.contributor.authorTilley, W.en
dc.contributor.authorStallcup, M.en
dc.contributor.authorPress, M.en
dc.contributor.authorCoetzee, G.en
dc.identifier.citationCancer Research, 2000; 60(21):5946-5949en
dc.description.abstractIn the present study, the role of BRCA1 in ligand-dependent androgen receptor (AR) signaling was assessed. In transfected prostate and breast cancer cell lines, BRCA1 enhanced AR-dependent transactivation of a probasin-derived reporter gene. The effects of BRCA1 were mediated through the NH2-terminal activation function (AF-1) of the receptor. Cotransfection of p160 coactivators markedly potentiated BRCA1-mediated enhancement of AR signaling. In addition, BRCA1 was shown to interact physically with both the AR and the p160 coactivator, glucocorticoid receptor interacting protein 1. These findings suggest that BRCA1 may directly modulate AR signaling and, therefore, may have implications regarding the proliferation of normal and malignant androgen-regulated tissues.en
dc.description.statementofresponsibilityJ.J. Park, R. A. Irvine, G. Buchanan, S. S. Koh, J. M. Park ... Wayne D. Tilley ... et al.en
dc.publisherAmerican Association for Cancer Researchen
dc.rightsCopyright status unknownen
dc.subjectProstate-cancer; proteins; domains; cellsen
dc.titleBreast cancer susceptibility gene 1 (BRCA1) is a coactivator of the androgen receptoren
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidTilley, W. [0000-0003-1893-2626]en
Appears in Collections:Medicine publications

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