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Type: Journal article
Title: The role of metal ions in the virulence and viability of bacterial pathogens
Author: Begg, S.
Citation: Biochemical Society Transactions, 2019; 47(1):77-87
Publisher: Portland Press
Issue Date: 2019
ISSN: 0300-5127
Statement of
Stephanie L. Begg
Abstract: Metal ions fulfil a plethora of essential roles within bacterial pathogens. In addition to acting as necessary cofactors for cellular proteins, making them indispensable for both protein structure and function, they also fulfil roles in signalling and regulation of virulence. Consequently, the maintenance of cellular metal ion homeostasis is crucial for bacterial viability and pathogenicity. It is therefore unsurprising that components of the immune response target and exploit both the essentiality of metal ions and their potential toxicity toward invading bacteria. This review provides a brief overview of the transition metal ions iron, manganese, copper and zinc during infection. These essential metal ions are discussed in the context of host modulation of bioavailability, bacterial acquisition and efflux, metal-regulated virulence factor expression and the molecular mechanisms that contribute to loss of viability and/or virulence during host-imposed metal stress.
Keywords: Host-Pathogen Interactions
Rights: © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
RMID: 0030106532
DOI: 10.1042/BST20180275
Grant ID:
Appears in Collections:Microbiology and Immunology publications

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