Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/120513
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Type: | Journal article |
Title: | Carbohydrates@MOFs |
Author: | Astria, E. Thonhofer, M. Ricco, R. Liang, W. Chemelli, A. Tarzia, A. Alt, K. Hagemeyer, C.E. Rattenberger, J. Schroettner, H. Wrodnigg, T. Amenitsch, H. Huang, D.M. Doonan, C.J. Falcaro, P. |
Citation: | Materials horizons, 2019; 6(5):969-977 |
Publisher: | Royal Society of Chemistry |
Issue Date: | 2019 |
ISSN: | 2051-6347 2051-6355 |
Statement of Responsibility: | Efwita Astria, Martin Thonhofer … Weibin Liang … David M. Huang, Christian J. Doonan, Paolo Falcaro ... et al. |
Abstract: | MOFs have demonstrated outstanding properties for the protection and controlled release of different bio-entities, from proteins to living cells. Carbohydrates, as pure molecules or as a component of proteins and cells, perform essential biological functions. Thus, an understanding of the role of carbohydrates in the formation of MOF-based bio-composites will facilitate their application to biotechnology and medicine. Here, we investigate the role of carbohydrate molecular weight and chemical functionalization in the formation of carbohydrate@MOF composites. We find that chemical functionalization, such as carboxylation, that leads to an enhancement of metal cation concentration at the surface of the molecule triggers the rapid self-assembly of the MOF material, zeolitic-imidazolate framework 8 (ZIF-8). Furthermore, we determine the encapsulation efficiency and measure the release properties of the carbohydrate under controlled conditions. Our findings show that MOFs can be used to prepare a new class of biocomposites for the delivery of carbohydrate-based therapeutics. |
Rights: | Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. |
DOI: | 10.1039/c8mh01611a |
Grant ID: | http://purl.org/au-research/grants/arc/DP170103531 http://purl.org/au-research/grants/nhmrc/APP1078118 http://purl.org/au-research/grants/nhmrc/APP1098867 |
Published version: | http://dx.doi.org/10.1039/c8mh01611a |
Appears in Collections: | Aurora harvest 4 Chemistry and Physics publications |
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hdl_120513.pdf | Published version | 4.7 MB | Adobe PDF | View/Open |
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