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https://hdl.handle.net/2440/120647
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dc.contributor.author | Lau, M.Y.Z. | - |
dc.contributor.author | Dharmage, S.C. | - |
dc.contributor.author | Burgess, J.A. | - |
dc.contributor.author | Win, A.K. | - |
dc.contributor.author | Lowe, A.J. | - |
dc.contributor.author | Lodge, C.J. | - |
dc.contributor.author | Perret, J. | - |
dc.contributor.author | Hui, J. | - |
dc.contributor.author | Thomas, P.S. | - |
dc.contributor.author | Giles, G. | - |
dc.contributor.author | Thompson, B.R. | - |
dc.contributor.author | Abramson, M.J. | - |
dc.contributor.author | Walters, E.H. | - |
dc.contributor.author | Matheson, M.C. | - |
dc.contributor.author | Allen, K.J. | - |
dc.contributor.author | Benke, G. | - |
dc.contributor.author | Dowty, J.G. | - |
dc.contributor.author | Erbas, B. | - |
dc.contributor.author | Feather, I.H. | - |
dc.contributor.author | Frith, P.A. | - |
dc.contributor.author | et al. | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Clinical and Experimental Allergy, 2019; 49(3):331-340 | - |
dc.identifier.issn | 0954-7894 | - |
dc.identifier.issn | 1365-2222 | - |
dc.identifier.uri | http://hdl.handle.net/2440/120647 | - |
dc.description.abstract | BACKGROUND:Markers of microbial exposure are thought to be associated with risk of allergic sensitization; however, the associations are inconsistent and may be related to gene-environment interactions. OBJECTIVE:To examine the relationship between polymorphisms in the CD14 gene and allergic sensitization and whether sibling exposure, as a marker of microbial exposure, modified this relationship. METHODS:We used data from the Tasmanian Longitudinal Health Study and the Melbourne Atopy Cohort Study. Two CD14 polymorphisms were genotyped. Allergic sensitization was defined by a positive response to a skin prick test. Sibling exposure was measured as cumulative exposure to siblings before age 6 months, 2 and 4 years. Logistic regression and multi-level mixed-effects logistic regression were used to examine the associations. Effect estimates across the cohorts were pooled using random-effects meta-analysis. RESULTS:CD14 SNPs were not individually associated with allergic sensitization in either cohort. In TAHS, cumulative sibling exposure before age 6 months, 2 and 4 years was each associated with a reduced risk of allergic sensitization at age 45 years. A similar effect was observed in MACS. Meta-analysis across the two cohorts showed consistent evidence of an interaction between cumulative sibling exposure before 6 months and the rs5744455-SNP (P = 0.001) but not with the rs2569190-SNP (P = 0.60). The pooled meta-analysis showed that the odds of sensitization with increasing cumulative exposure to sibling before 6 months of age was 20.9% smaller in those with the rs5744455-C-allele than the T-allele (OR = 0.83 vs 1.05, respectively). CONCLUSION AND CLINICAL RELEVANCE:Cumulative sibling exposure reduced the risk of sensitization from childhood to middle age in genetically susceptible individuals. | - |
dc.description.statementofresponsibility | Melisa Y. Z. Lau, Shyamali C. Dharmage, John A. Burgess, Aung K. Win, Adrian J. Lowe ... Christopher A. ... et al. (For the investigators of the TAHS and MACS) | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2018 John Wiley & Sons Ltd. | - |
dc.source.uri | http://dx.doi.org/10.1111/cea.13290 | - |
dc.subject | Allergy; allergic sensitization; CD14; gene‐environment interaction; genetics; siblings | - |
dc.title | Early-life exposure to sibling modifies the relationship between CD14 polymorphisms and allergic sensitization | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/cea.13290 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/454856 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Barton, C.A. [0000-0001-9823-7425] | - |
Appears in Collections: | Aurora harvest 4 Public Health publications |
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