Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/120647
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dc.contributor.authorLau, M.Y.Z.-
dc.contributor.authorDharmage, S.C.-
dc.contributor.authorBurgess, J.A.-
dc.contributor.authorWin, A.K.-
dc.contributor.authorLowe, A.J.-
dc.contributor.authorLodge, C.J.-
dc.contributor.authorPerret, J.-
dc.contributor.authorHui, J.-
dc.contributor.authorThomas, P.S.-
dc.contributor.authorGiles, G.-
dc.contributor.authorThompson, B.R.-
dc.contributor.authorAbramson, M.J.-
dc.contributor.authorWalters, E.H.-
dc.contributor.authorMatheson, M.C.-
dc.contributor.authorAllen, K.J.-
dc.contributor.authorBenke, G.-
dc.contributor.authorDowty, J.G.-
dc.contributor.authorErbas, B.-
dc.contributor.authorFeather, I.H.-
dc.contributor.authorFrith, P.A.-
dc.contributor.authoret al.-
dc.date.issued2019-
dc.identifier.citationClinical and Experimental Allergy, 2019; 49(3):331-340-
dc.identifier.issn0954-7894-
dc.identifier.issn1365-2222-
dc.identifier.urihttp://hdl.handle.net/2440/120647-
dc.description.abstractBACKGROUND:Markers of microbial exposure are thought to be associated with risk of allergic sensitization; however, the associations are inconsistent and may be related to gene-environment interactions. OBJECTIVE:To examine the relationship between polymorphisms in the CD14 gene and allergic sensitization and whether sibling exposure, as a marker of microbial exposure, modified this relationship. METHODS:We used data from the Tasmanian Longitudinal Health Study and the Melbourne Atopy Cohort Study. Two CD14 polymorphisms were genotyped. Allergic sensitization was defined by a positive response to a skin prick test. Sibling exposure was measured as cumulative exposure to siblings before age 6 months, 2 and 4 years. Logistic regression and multi-level mixed-effects logistic regression were used to examine the associations. Effect estimates across the cohorts were pooled using random-effects meta-analysis. RESULTS:CD14 SNPs were not individually associated with allergic sensitization in either cohort. In TAHS, cumulative sibling exposure before age 6 months, 2 and 4 years was each associated with a reduced risk of allergic sensitization at age 45 years. A similar effect was observed in MACS. Meta-analysis across the two cohorts showed consistent evidence of an interaction between cumulative sibling exposure before 6 months and the rs5744455-SNP (P = 0.001) but not with the rs2569190-SNP (P = 0.60). The pooled meta-analysis showed that the odds of sensitization with increasing cumulative exposure to sibling before 6 months of age was 20.9% smaller in those with the rs5744455-C-allele than the T-allele (OR = 0.83 vs 1.05, respectively). CONCLUSION AND CLINICAL RELEVANCE:Cumulative sibling exposure reduced the risk of sensitization from childhood to middle age in genetically susceptible individuals.-
dc.description.statementofresponsibilityMelisa Y. Z. Lau, Shyamali C. Dharmage, John A. Burgess, Aung K. Win, Adrian J. Lowe ... Christopher A. ... et al. (For the investigators of the TAHS and MACS)-
dc.language.isoen-
dc.publisherWiley-
dc.rights© 2018 John Wiley & Sons Ltd.-
dc.source.urihttp://dx.doi.org/10.1111/cea.13290-
dc.subjectAllergy; allergic sensitization; CD14; gene‐environment interaction; genetics; siblings-
dc.titleEarly-life exposure to sibling modifies the relationship between CD14 polymorphisms and allergic sensitization-
dc.typeJournal article-
dc.identifier.doi10.1111/cea.13290-
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/454856-
pubs.publication-statusPublished-
dc.identifier.orcidBarton, C.A. [0000-0001-9823-7425]-
Appears in Collections:Aurora harvest 4
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