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https://hdl.handle.net/2440/121742
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Type: | Journal article |
Title: | Interleukin-11 is the dominant Il-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically |
Author: | Putoczki, T.L. Thiem, S. Loving, A. Busuttil, R.A. Wilson, N.J. Ziegler, P.K. Nguyen, P.M. Preaudet, A. Farid, R. Edwards, K.M. Boglev, Y. Luwor, R.B. Jarnicki, A. Horst, D. Boussioutas, A. Heath, J.K. Sieber, O.M. Pleines, I. Kile, B.T. Nash, A. et al. |
Citation: | Cancer Cell, 2013; 24(2):257-271 |
Publisher: | Cell Press |
Issue Date: | 2013 |
ISSN: | 1535-6108 1878-3686 |
Statement of Responsibility: | Tracy L.Putoczki, Stefan Thiem, Andrea Loving, Rita A.Busuttil, Nicholas J.Wilson ... Benjamin T. Kile ... et al. |
Abstract: | Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives many of the cancer "hallmarks" through downstream activation of the gp130/STAT3 signaling pathway. However, we show that the related cytokine IL-11 has a stronger correlation with elevated STAT3 activation in human gastrointestinal cancers. Using genetic mouse models, we reveal that IL-11 has a more prominent role compared to IL-6 during the progression of sporadic and inflammation-associated colon and gastric cancers. Accordingly, in these models and in human tumor cell line xenograft models, pharmacologic inhibition of IL-11 signaling alleviated STAT3 activation, suppressed tumor cell proliferation, and reduced the invasive capacity and growth of tumors. Our results identify IL-11 signaling as a potential therapeutic target for the treatment of gastrointestinal cancers. |
Keywords: | Molecular Targeted Therapy |
Rights: | © 2013 Elsevier Inc. |
DOI: | 10.1016/j.ccr.2013.06.017 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1008614 http://purl.org/au-research/grants/nhmrc/487922 http://purl.org/au-research/grants/nhmrc/1016647 |
Published version: | http://dx.doi.org/10.1016/j.ccr.2013.06.017 |
Appears in Collections: | Aurora harvest 8 Medical Sciences publications |
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