Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/121944
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Type: | Journal article |
Title: | Selective biocatalytic hydroxylation of unactivated methylene C-H bonds in cyclic alkyl substrates |
Author: | Sarkar, M.R. Dasgupta, S. Pyke, S.M. Bell, S.G. |
Citation: | Chemical Communications, 2019; 55(34):5029-5032 |
Publisher: | Royal Society of Chemistry |
Issue Date: | 2019 |
ISSN: | 1359-7345 1364-548X |
Statement of Responsibility: | Md Raihan Sarkar, Samrat Dasgupta, Simon M. Pyke and Stephen G. Bell |
Abstract: | The cytochrome P450 monooxygenase CYP101B1 from Novosphingobium aromaticivorans selectively hydroxylated methylene C-H bonds in cycloalkyl rings. Cycloketones and cycloalkyl esters containing C6, C8, C10 and C12 rings were oxidised with high selectively on the opposite side of the ring to the carbonyl substituent. Cyclodecanone was oxidised to oxabicycloundecanol derivatives in equilibrium with the hydroxycyclodecanones. |
Keywords: | Biocatalytic hydroxylation |
Rights: | This journal is © The Royal Society of Chemistry 2019 |
DOI: | 10.1039/c9cc02060h |
Published version: | http://dx.doi.org/10.1039/c9cc02060h |
Appears in Collections: | Aurora harvest 8 Chemistry publications |
Files in This Item:
File | Description | Size | Format | |
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hdl_121944.pdf | Accepted version | 649.87 kB | Adobe PDF | View/Open |
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