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https://hdl.handle.net/2440/128306
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Type: | Journal article |
Title: | Crosstalk between cGAS-STING signaling and cell death |
Author: | Murthy, A.M.V. Robinson, N. Kumar, S. |
Citation: | Cell Death and Differentiation, 2020; 27(11):2989-3003 |
Publisher: | Springer Nature |
Issue Date: | 2020 |
ISSN: | 1350-9047 1476-5403 |
Statement of Responsibility: | Ambika M. V. Murthy, Nirmal Robinson and Sharad Kumar |
Abstract: | Cytosolic nucleic acid sensors have a critical role in detecting endogenous nucleic acids to initiate innate immune responses during microbial infections and/or cell death. Several seminal studies over the past decade have delineated the conserved mechanism of cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and the downstream signaling adapter stimulator of interferon genes (STING) in mediating innate immune signaling pathways as a host defense mechanism. Besides the predominant role in microbial infections and inflammatory diseases, there is an increased attention on alternative functional responses of cGAS-STING-mediated signaling. Here we review the complexity of interactions between the cGAS-STING signaling and cell death pathways. A better understanding of molecular mechanisms of this interplay is important with regard to the development of new therapeutics targeting cGAS-STING signaling in cancer, infectious, and chronic inflammatory diseases. |
Keywords: | Animals Humans Neoplasms Disease Susceptibility Nucleotidyltransferases Membrane Proteins Signal Transduction Cell Death Immunity, Innate Infections |
Description: | Published online: 18 September 2020 |
Rights: | © The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2020 |
DOI: | 10.1038/s41418-020-00624-8 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1103006 http://purl.org/au-research/grants/nhmrc/1144500 http://purl.org/au-research/grants/nhmrc/1156601 |
Published version: | http://dx.doi.org/10.1038/s41418-020-00624-8 |
Appears in Collections: | Aurora harvest 8 Biochemistry publications |
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