Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/128383
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DC Field | Value | Language |
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dc.contributor.author | Ebert, L.M. | - |
dc.contributor.author | MacRaild, S.E. | - |
dc.contributor.author | Davis, I.D. | - |
dc.contributor.author | Cebon, J. | - |
dc.contributor.author | Chen, W. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Journal of Immunological Methods, 2012; 377(1-2):56-61 | - |
dc.identifier.issn | 0022-1759 | - |
dc.identifier.issn | 1872-7905 | - |
dc.identifier.uri | http://hdl.handle.net/2440/128383 | - |
dc.description.abstract | Antigenic epitopes recognized by FoxP3(+) regulatory T cells (Treg) are poorly defined, largely due to a lack of assays for determining Treg specificity. We have developed a novel approach for detecting human Treg specific to peptide antigen, utilizing down-regulation of surface CD3 as a read-out of antigen recognition. Culture conditions and re-stimulation time have been optimized, allowing the detection of even very rare Treg, such as those specific to tumor antigens. | - |
dc.description.statementofresponsibility | Lisa M.Ebert, Sarah E.MacRaild, Ian D.Davis, Jonathan Cebon, Weisan Chen | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2012 Elsevier B.V. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.jim.2012.01.004 | - |
dc.subject | Fox P3, Antigen-specific regulatory T cells; CD3 down-regulation; NY-ESO-1 | - |
dc.title | A novel method for detecting antigen-specific human regulatory T cells | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.jim.2012.01.004 | - |
dc.relation.grant | NHMRC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Ebert, L.M. [0000-0002-8041-9666] | - |
Appears in Collections: | Aurora harvest 8 Biochemistry publications |
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