Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Adaptors as the regulators of HECT ubiquitin ligases
Author: Shah, S.S.
Kumar, S.
Citation: Cell Death and Differentiation, 2021; 28(2):455-472
Publisher: Springer
Issue Date: 2021
ISSN: 1350-9047
Statement of
Sonia Shalini Shah and Sharad Kumar
Abstract: The HECT (homologous to E6AP C-terminus) ubiquitin ligases (E3s) are a small family of highly conserved enzymes involved in diverse cellular functions and pathological conditions. Characterised by a C-terminal HECT domain that accepts ubiquitin from E2 ubiquitin conjugating enzymes, these E3s regulate key signalling pathways. The activity and functional regulation of HECT E3s are controlled by several factors including post-translational modifications, inter- and intramolecular interactions and binding of co-activators and adaptor proteins. In this review, we focus on the regulation of HECT E3s by accessory proteins or adaptors and discuss various ways by which adaptors mediate their regulatory roles to affect physiological outcomes. We discuss common features that are conserved from yeast to mammals, regardless of the type of E3s as well as shed light on recent discoveries explaining some existing enigmas in the field.
Rights: © The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2021, corrected publication 2021
DOI: 10.1038/s41418-020-00707-6
Grant ID:
Appears in Collections:Aurora harvest 4
Biochemistry publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.