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Type: Journal article
Title: New potent inhibitors of aquaporins: silver and gold compounds inhibit aquaporins of plant and human origin
Author: Niemietz, C.
Tyerman, S.
Citation: FEBS Letters, 2002; 531(3):443-447
Publisher: Elsevier Science BV
Issue Date: 2002
ISSN: 0014-5793
Statement of
Christa M. Niemietz and Stephen D. Tyerman
Abstract: Silver and gold compounds were tested as potential inhibitors of aquaporins of plant- and human origin. Silver as AgNO₃ or silver sulfadiazine inhibited with high potency (EC₅₀ 1–10 μM) the water permeability of the peribacteroid membrane from soybean (containing Nodulin 26), the water permeability of plasma membrane from roots (containing plasma membrane integral proteins), and the water permeability of human red cells (containing aquaporin 1). Gold as HAuCl₄ was less effective but still inhibited peribacteroid membrane water permeability (EC₅₀=10 μM). Silver and gold are more potent inhibitors of aquaporins than the presently widely used mercury containing compounds.
Keywords: Aquaporin; silver inhibition; gold inhibition; mercury inhibition; nodulin 26; plasma membrane integral protein
Description: Copyright © 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V.
RMID: 0020021121
DOI: 10.1016/S0014-5793(02)03581-0
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Appears in Collections:Wine Science publications

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