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https://hdl.handle.net/2440/130043
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Type: | Journal article |
Title: | Effects of aspirin on the long-term management of depression in older people: a double-blind randomised placebo-controlled trial |
Author: | Berk, M. Agustini, B. Woods, R.L. Nelson, M.R. Shah, R.C. Reid, C.M. Storey, E. Fitzgerald, S.M. Lockery, J.E. Wolfe, R. Mohebbi, M. Dodd, S. Murray, A.M. Stocks, N. Fitzgerald, P.B. Mazza, C. McNeil, J.J. |
Citation: | Molecular Psychiatry, 2021; 26(9):5161-5170 |
Publisher: | Springer |
Issue Date: | 2021 |
ISSN: | 1359-4184 1476-5578 |
Statement of Responsibility: | Michael Berk, Bruno Agustini, Robyn L. Woods, Mark R. Nelson, Raj C. Shah, Christopher M. Reid ... et al. |
Abstract: | Late-life depression is common and often inadequately managed using existing therapies. Depression is also associated with increased markers of inflammation, suggesting a potential role for anti-inflammatory agents. ASPREE-D is a sub-study of ASPREE, a large multi-centre, population-based, double-blind, placebo-controlled trial of aspirin vs placebo in older Australian and American adults (median follow-up: 4.7 years) of whom 1879 were depressed at baseline. Participants were given 100 mg daily dose of aspirin or placebo. Depressive symptoms were assessed annually using the validated, self-rated short version of the Center for Epidemiological Studies Depression scale. There was a significant increase in depressive scores (0.6; 95% CI 0.2 to 0.9; χ2 (1)=10.37; p=0.001) and a decreased score in the mental health component of a quality of life scale (–0.7; 95% CI –1.4 to –0.1; χ2 (1)=4.74; p=0.029) in the aspirin group compared to the placebo group. These effects were greater in the first year of follow-up and persisted throughout the study, albeit with small to very small effect sizes. This study failed to demonstrate any benefit of aspirin in the long-term course of depression in this community-dwelling sample of older adults over a 5-year period, and identified an adverse effect of aspirin in the course of depression in those with pre-existing depressive symptoms. |
Keywords: | Humans Aspirin Double-Blind Method Depression Quality of Life Aged Australia |
Description: | Published online: 27 January 2021 |
Rights: | © The Author(s), under exclusive licence to Springer Nature Limited 2021. |
DOI: | 10.1038/s41380-021-01020-5 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1127060 http://purl.org/au-research/grants/nhmrc/1081901 http://purl.org/au-research/grants/nhmrc/334047 http://purl.org/au-research/grants/nhmrc/1059660 http://purl.org/au-research/grants/nhmrc/1156072 |
Published version: | http://dx.doi.org/10.1038/s41380-021-01020-5 |
Appears in Collections: | Aurora harvest 4 General Practice publications |
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