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Type: Journal article
Title: Tailoring Additively Manufactured Titanium Implants for Short-Time Pediatric Implantations with Enhanced Bactericidal Activity
Author: Maher, S.
Linklater, D.
Rastin, H.
Le Yap, P.
Ivanova, E.P.
Losic, D.
Citation: ChemMedChem: chemistry enabling drug discovery, 2022; 17(2):e202100580-1-e202100580-13
Publisher: Wiley
Issue Date: 2022
ISSN: 1860-7179
Statement of
Shaheer Maher, Denver Linklater, Hadi Rastin, Pei Le Yap, Elena P. Ivanova, and Dusan Losic
Abstract: Paediatric titanium (Ti) implants are used for the short-term fixation of fractures, after which they are removed. However, bone overgrowth on the implant surface can complicate their removal. The current Ti implants research focuses on improving their osseointegration and antibacterial properties for long-term use while overlooking the requirements of temporary implants. This paper presents the engineering of additively manufactured Ti implants with antibacterial properties and prevention of bone cell overgrowth. 3D-printed implants were fabricated followed by electrochemical anodization to generate vertically aligned titania nanotubes (TNTs) on the surface with specific diameters (∼100 nm) to reduce cell attachment and proliferation. To achieve enhanced antibacterial performance, TNTs were coated with gallium nitrate as antibacterial agent. The physicochemical characteristics of these implants assessed by the attachment, growth and viability of osteoblastic MG-63 cells showed significantly reduced cell attachment and proliferation, confirming the ability of TNTs surface to avoid cell overgrowth. Gallium coated TNTs showed strong antibacterial activity against S. aureus and P. aeruginosa with reduced bacterial attachment and high rates of bacterial death. Thus a new approach for the engineering of temporary Ti implants with enhanced bactericidal properties with reduced bone cell attachment is demonstrated as a new strategy toward a new generation of short-term implants in paediatrics.
Keywords: Titanium implants
additive manufacturing
titania nanotubes
Description: Version of record online: November 3, 2021
Rights: © 2021 Wiley-VCH GmbH
DOI: 10.1002/cmdc.202100580
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Appears in Collections:ARC Research Hub for Graphene Enabled Industry Transformation publications
Chemical Engineering publications

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