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https://hdl.handle.net/2440/133510
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Type: | Journal article |
Title: | Brain structural and microstructural alterations associated with cerebral palsy and motor impairments in adolescents born extremely preterm and/or extremely low birthweight |
Author: | Kelly, C.E. Chan, L. Burnett, A.C. Lee, K.J. Connelly, A. Anderson, P.J. Doyle, L.W. Cheong, J.L.Y. Thompson, D.K. |
Citation: | Developmental Medicine and Child Neurology, 2015; 57(12):1168-1175 |
Publisher: | Wiley |
Issue Date: | 2015 |
ISSN: | 0012-1622 1469-8749 |
Statement of Responsibility: | Claire E Kelly, Linda Chan, Alice C Burnett, Katherine J Lee, Alan Connelly, Peter J Anderson ... et. |
Abstract: | To elucidate neurobiological changes underlying motor impairments in adolescents born extremely preterm (gestation <28wks) and/or with extremely low birthweight (ELBW, <1000g), our aims were the following: (1) to compare corticospinal tract (CST) microstructure and primary motor cortex (M1) volume, area, and thickness between extremely preterm/ELBW adolescents and a comparison group with normal birthweight (>2499g); (2) to compare CST microstructure and M1 volume, area, and thickness between extremely preterm/ELBW adolescents with cerebral palsy (CP), motor impairment without CP, and no motor impairment; and (3) to investigate associations between CST microstructure and M1 measures.This study used diffusion and structural magnetic resonance imaging to examine the CST and M1 in a geographical cohort of 191 extremely preterm/ELBW adolescents (mean age 18y 2.4mo [SD 9.6mo]; 87 males, 104 females) and 141 adolescents in the comparison group (mean age 18y 1.2mo [SD 9.6mo]; 59 males, 82 females).Extremely preterm/ELBW adolescents had higher CST axial, radial, and mean diffusivities and lower M1 thickness than the comparison group. Extremely preterm/ELBW adolescents with CP had higher CST diffusivities than non-motor-impaired extremely preterm/ELBW adolescents. CST diffusivities correlated with M1 volume and area.Extremely preterm/ELBW adolescents have altered CST microstructure, which is associated with CP. Furthermore, the results elucidate how CST and M1 alterations interrelate to potentially influence motor function in extremely preterm/ELBW adolescents. |
Keywords: | Cohort Studies |
Rights: | © 2015 Mac Keith Press. |
DOI: | 10.1111/dmcn.12854 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/491246 http://purl.org/au-research/grants/nhmrc/546519 http://purl.org/au-research/grants/nhmrc/628371 http://purl.org/au-research/grants/nhmrc/1053787 http://purl.org/au-research/grants/nhmrc/1012236 http://purl.org/au-research/grants/nhmrc/1053609 |
Published version: | http://dx.doi.org/10.1111/dmcn.12854 |
Appears in Collections: | Paediatrics publications |
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