Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/134619
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Type: | Journal article |
Title: | Signaling Mechanisms and Pharmacological Modulators Governing Diverse Aquaporin Functions in Human Health and Disease |
Author: | Wagner, K. Unger, L. Salman, M.M. Kitchen, P. Bill, R.M. Yool, A.J. |
Citation: | International Journal of Molecular Sciences, 2022; 23(3):1388-1388 |
Publisher: | MDPI AG |
Issue Date: | 2022 |
ISSN: | 1661-6596 1422-0067 |
Statement of Responsibility: | Kim Wagner, Lucas Unger, Mootaz M. Salman, Philip Kitchen, Roslyn M. Bill, and Andrea J. Yool |
Abstract: | The aquaporins (AQPs) are a family of small integral membrane proteins that facilitate the bidirectional transport of water across biological membranes in response to osmotic pressure gradients as well as enable the transmembrane diffusion of small neutral solutes (such as urea, glycerol, and hydrogen peroxide) and ions. AQPs are expressed throughout the human body. Here, we review their key roles in fluid homeostasis, glandular secretions, signal transduction and sensation, barrier function, immunity and inflammation, cell migration, and angiogenesis. Evidence from a wide variety of studies now supports a view of the functions of AQPs being much more complex than simply mediating the passive flow of water across biological membranes. The discovery and development of small-molecule AQP inhibitors for research use and therapeutic development will lead to new insights into the basic biology of and novel treatments for the wide range of AQP-associated disorders. |
Keywords: | aquaporin (AQP); membranes; water; fluid; secretion; osmosis; facilitated diffusion; signaling |
Rights: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
DOI: | 10.3390/ijms23031388 |
Grant ID: | http://purl.org/au-research/grants/arc/19ARC_DP190 101745 |
Published version: | http://dx.doi.org/10.3390/ijms23031388 |
Appears in Collections: | Medical Sciences publications |
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hdl_134619.pdf | 4.31 MB | Adobe PDF | View/Open |
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