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Type: Journal article
Title: Antibacterial silver and gold complexes of imidazole and 1,2,4-triazole derived N-heterocyclic carbenes
Author: Mather, J.C.
Wyllie, J.A.
Hamilton, A.
Soares da Costa, T.P.
Barnard, P.J.
Citation: Dalton Transactions: an international journal of inorganic chemistry, 2022; 51(32):12056-12070
Publisher: Royal Society of Chemistry
Issue Date: 2022
ISSN: 1477-9226
Statement of
Joel C. Mather, Jessica A. Wyllie, Alex Hamilton, Tatiana P. Soares da Costa and Peter J. Barnard
Abstract: A series of gold(I) (4a–4h, 5a–5b) and silver(I) (3a–3h) complexes of 1,2,4-triazolylidene and imidazolylidene based N-heterocyclic carbene ligands were prepared and the antibacterial activities of these complexes have been evaluated. The complexes were characterised using 1H-NMR, 13C-NMR, HRMS and in the cases of 3a, 3c, 4b and 5b by X-ray crystallography. The gold(I) complexes with phenyl substituents (4a–4d) were found to have potent antibacterial activity against Gram-positive bacteria, with the complexes of the 1,2,4-triazolylidene ligands being more active (4c, MIC = 4–8 μg mL−1 against Enterococcus faecium and 2 μg mL−1 against Staphylococcus aureus) than the analogous imidazolylidene complexes 4a and 4b (4a, MIC = 64 μg mL−1 against E. faecium and 2–4 μg mL−1 against S. aureus). Two of the silver(I) complexes have promising antibacterial activity against Acinetobacter baumannii (3f, MIC = 2–4 μg mL−1 and 3g, MIC = 2 μg mL−1). Silver(I) complex 3f and gold(I) complex 4c were tested against multi-drug resistant bacterial strains and high levels of antibacterial activity were observed. The potential for antibacterial resistance to develop against these metal containing complexes was investigated and significantly, no resistance was observed upon continuous treatment, whilst resistance was developed against the widely used broad-spectrum antibiotic ciprofloxacin in the same bacterial strains, under the conditions tested. The solution and gas phase stabilities of the complexes have been investigated using a combination of 1H-NMR, HRMS and detailed computational mechanistic studies were undertaken to gain insights into the possible decomposition reactions for silver complexes in aqueous solution.
Keywords: Staphylococcus aureus
Anti-Bacterial Agents
Microbial Sensitivity Tests
Coordination Complexes
Description: First published 15 Jul 2022
Rights: This journal is © The Royal Society of Chemistry 2022
DOI: 10.1039/d2dt01657e
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Appears in Collections:Chemistry publications

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