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dc.contributor.authorMullany, S.-
dc.contributor.authorMarshall, H.-
dc.contributor.authorDiaz-Torres, S.-
dc.contributor.authorBerry, E.C.-
dc.contributor.authorSchmidt, J.M.-
dc.contributor.authorThomson, D.-
dc.contributor.authorQassim, A.-
dc.contributor.authorTo, M.-S.-
dc.contributor.authorDimasi, D.-
dc.contributor.authorKuot, A.-
dc.contributor.authorKnight, L.S.W.-
dc.contributor.authorHollitt, G.-
dc.contributor.authorKolovos, A.-
dc.contributor.authorSchulz, A.-
dc.contributor.authorLake, S.-
dc.contributor.authorMills, R.A.-
dc.contributor.authorAgar, A.-
dc.contributor.authorGalanopoulos, A.-
dc.contributor.authorLanders, J.-
dc.contributor.authorMitchell, P.-
dc.contributor.authoret al.-
dc.identifier.citationOphthalmology Science, 2022; 2(2):100159-100159-
dc.description.abstractPurpose: To investigate the association between the apolipoprotein E (APOE) E4 dementia-risk allele and prospective longitudinal retinal thinning in a cohort study of suspect and early manifest glaucoma. Design: Retrospective analysis of prospective cohort data. Participants: This study included all available eyes from participants recruited to the Progression Risk of Glaucoma: Relevant SNPs [single nucleotide polymorphisms] with Significant Association (PROGRESSA) study with genotyping data from which APOE genotypes could be determined. Methods: Apolipoprotein E alleles and genotypes were determined in PROGRESSA, and their distributions were compared with an age-matched and ancestrally matched normative cohort, the Blue Mountains Eye Study. Structural parameters of neuroretinal atrophy measured using spectral-domain OCT were compared within the PROGRESSA cohort on the basis of APOE E4 allele status. Main Outcome Measures: Longitudinal rates of thinning in the macular ganglion celleinner plexiform layer (mGCIPL) complex and the peripapillary retinal nerve fiber layer (pRNFL). Results: Rates of mGCIPL complex thinning were faster in participants harboring ≥1 copies of the APOE E4 allele (b ¼ e0.13 mm/year; P ≤0.001). This finding was strongest in eyes affected by normal-tension glaucoma (NTG; b ¼ e0.20 mm/year; P ¼ 0.003). Apolipoprotein E E4 allele carriers were also more likely to be lost to followup (P ¼ 0.01) and to demonstrate a thinner average mGCIPL complex (70.9 mm vs. 71.9 mm; P ¼ 0.011) and pRNFL (77.6 mm vs. 79.2 mm; P ¼ 0.045) after a minimum of 3 years of monitoring. Conclusions: The APOE E4 allele was associated with faster rates of mCGIPL complex thinning, particularly in eyes with NTG. These results suggest that the APOE E4 allele may be a risk factor for retinal ganglion cell degeneration in glaucoma.-
dc.description.statementofresponsibilitySean Mullany, Henry Marshall, Santiago Diaz-Torres, Ella C. Berry, Joshua M. Schmidt, Daniel Thomson, Ayub Qassim, Minh-Son To, David Dimasi, Abraham Kuot, Lachlan S.W. Knight, Georgina Hollitt, Antonia Kolovos, Angela Schulz, Stewart Lake, Richard A. Mills, Ashish Agar, Anna Galanopoulos, John Landers, Paul Mitchell, Paul R. Healey, Stuart L. Graham, Alex W. Hewitt, Emmanuelle Souzeau, Mark M. Hassall, Sonja Klebe, Stuart MacGregor, Puya Gharahkhani, Robert J. Casson, Owen M. Siggs, Jamie E. Craig-
dc.publisherElsevier BV-
dc.rightsª 2022 by the American Academy of Ophthalmology. This is an open access article under the CC BY-NC-ND license ( licenses/by-nc-nd/4.0/).-
dc.subjectAPOE, apolipoprotein E-
dc.subjectApolipoprotein E-
dc.subjectBMES, Blue Mountains Eye Study-
dc.subjectHTG, high-tension glaucoma-
dc.subjectHVF, Humphrey visual field-
dc.subjectIOP, intraocular pressure-
dc.subjectNTG, normal-tension glaucoma-
dc.subjectPOAG, primary open-angle glaucoma-
dc.subjectPROGRESSA, Progression Risk of Glaucoma: Relevant SNPs with Significant Association-
dc.subjectRetinal Neurodegeneration-
dc.subjectSD OCT, spectral-domain OCT-
dc.subjectSE, standard error-
dc.subjectSNP, single nucleotide polymorphism-
dc.subjectmGCIPL, macular ganglion cell–inner plexiform layer-
dc.subjectpRNFL, peripapillary retinal nerve fiber layer-
dc.titleThe APOE E4 allele is associated with faster rates of neuroretinal thinning in a prospective cohort study of suspect and early glaucoma-
dc.typeJournal article-
dc.identifier.orcidSchmidt, J.M. [0000-0002-5862-7389]-
dc.identifier.orcidHassall, M.M. [0000-0002-6180-7954]-
dc.identifier.orcidCasson, R.J. [0000-0003-2822-4076]-
Appears in Collections:Biochemistry publications

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