Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Naloxone and its quaternary derivative, naloxone methiodide, have differing affinities for m, d, k and opiod receptors in mouse brain homogenates|
|Citation:||Brain Research, 2003; 964(2):302-305|
|Publisher:||Elsevier Science Bv|
|Tanya Lewanowitsch and Rodney James Irvine|
|Abstract:||Naloxone and naloxone methiodide both act on opioid receptors but naloxone methiodide has limited access to the brain. Naloxone methiodide has been shown to have a lower affinity for opioid receptors than naloxone in the rat and guinea pig but has not been tested in the mouse. We aimed to investigate this by using [3H]DAMGO, [3H]DPDPE and [3H]U-69,593 to compare the ability of naloxone and naloxone methiodide to displace binding to μ, δ and κ opioid receptors in mouse brain homogenates. Significant binding was observed for each receptor type and the binding affinity for naloxone versus naloxone methiodide was found to be 15:1 for μ, 6:1 for κ and 330:1 for δ receptors. Therefore, naloxone methiodide does have a lower affinity for opioid receptors than naloxone in mouse brain tissue, which must be taken into consideration in experimental designs.|
|Keywords:||Naloxone; Naloxone methiodide; Opioid receptor; mouse|
|Description:||Copyright © 2002 Elsevier Science B.V. All rights reserved.|
|Appears in Collections:||Pharmacology publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.