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|Title:||Comparison of tincture of opium and methadone to control opioid withdrawal in a Thai treatment centre|
|Citation:||British Journal of Clinical Pharmacology, 2004; 58(5):536-541|
|Publisher:||Blackwell Publishing Ltd|
|Jaroon Jittiwutikarn, Robert Ali, Jason M. White, Felix Bochner, Andrew A. Somogyi and David J. R. Foster|
|Abstract:||AIMS: To evaluate the effectiveness of oral tincture of opium (TOP) and methadone to control opioid withdrawal in patients in northern Thailand. METHODS: Open label, parallel group study in an inpatient facility compared 15 former heroin users receiving methadone 5–20 mg 12 hourly with 15 former opium smokers receiving TOP (3.33–10 mg morphine equivalents 12 hourly). At 0, 1, 3 and 8 h, blood, withdrawal scores and subjective opioid effects were collected. RESULTS: There was a reciprocal association between withdrawal scores/direct subjective opioid effects and plasma (R)-methadone, but not plasma morphine, concentrations. Withdrawal scores at the time of dosing were higher in the TOP patients (9.1 ± 3) than in the methadone patients (4.5 ± 4.6) and in the TOP patients were significantly (P = 0.001) attenuated at 3 and 8 h. CONCLUSIONS: At the doses used, TOP was inferior to methadone in suppressing withdrawal. It could prove to be a cost effective and valuable drug, but only after dose size and frequency are further investigated.|
|Keywords:||Humans; Opioid-Related Disorders; Substance Withdrawal Syndrome; Methadone; Opium; Morphine; Narcotics; Administration, Oral; Adult; Middle Aged|
|Description:||The definitive version is available at www.blackwell-synergy.com|
|Appears in Collections:||Pharmacology publications|
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