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Type: Journal article
Title: Association between CYP2C19 genotype and proguanil oxidative polymorphism.
Author: Coller, J.
Somogyi, A.
Bochner, F.
Citation: British Journal of Clinical Pharmacology, 1997; 43(6):659-660
Issue Date: 1997
ISSN: 0306-5251
Abstract: <h4>Aims</h4>To examine the relationship between proguanil metabolism and the number of mutations in CYP2C19 by comparing the CYP2C19 genotype and proguanil phenotype of 10 subjects.<h4>Methods</h4>Partial clearance and urinary metabolic ratio data were obtained from a previous study of 10 subjects [5]. Analysis of CYP2C19 genotypes was performed using PCR amplification followed by restriction endonuclease digestion of genomic DNA from a blood sample.<h4>Results</h4>The intrinsic partial clearance of PG to CG ranged from 0.41-10.11 h-1, and was related to the number of functional CYP2C19 alleles present. Genotypic PMs had metabolic ratios > 13, while genotypic heterozygote EMs had metabolic ratios < 9.<h4>Conclusions</h4>Proguanil may be a suitable phenotyping probe for the CYP2C19 genetic polymorphism, however the exact antimode of the urinary metabolic ratio chosen to separate poor and extensive metabolisers needs further investigation.
Keywords: Humans; Cytochrome P-450 Enzyme System; Aryl Hydrocarbon Hydroxylases; DNA Restriction Enzymes; Mixed Function Oxygenases; DNA; Antimetabolites; Administration, Oral; Polymerase Chain Reaction; Gene Expression Regulation, Enzymologic; Genotype; Heterozygote; Phenotype; Polymorphism, Genetic; Alleles; Asian Continental Ancestry Group; European Continental Ancestry Group; Proguanil; Cytochrome P-450 CYP2C19
RMID: 0030003436
DOI: 10.1046/j.1365-2125.1997.00596.x
Appears in Collections:Pharmacology publications

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