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|Title:||Association between CYP2C19 genotype and proguanil oxidative polymorphism.|
|Citation:||British Journal of Clinical Pharmacology, 1997; 43(6):659-660|
|Publisher:||BLACKWELL SCIENCE LTD|
|Abstract:||AIMS:To examine the relationship between proguanil metabolism and the number of mutations in CYP2C19 by comparing the CYP2C19 genotype and proguanil phenotype of 10 subjects. METHODS:Partial clearance and urinary metabolic ratio data were obtained from a previous study of 10 subjects . Analysis of CYP2C19 genotypes was performed using PCR amplification followed by restriction endonuclease digestion of genomic DNA from a blood sample. RESULTS:The intrinsic partial clearance of PG to CG ranged from 0.41-10.11 h-1, and was related to the number of functional CYP2C19 alleles present. Genotypic PMs had metabolic ratios > 13, while genotypic heterozygote EMs had metabolic ratios < 9. CONCLUSIONS:Proguanil may be a suitable phenotyping probe for the CYP2C19 genetic polymorphism, however the exact antimode of the urinary metabolic ratio chosen to separate poor and extensive metabolisers needs further investigation.|
|Keywords:||Humans; Cytochrome P-450 Enzyme System; Aryl Hydrocarbon Hydroxylases; DNA Restriction Enzymes; Mixed Function Oxygenases; DNA; Antimetabolites; Administration, Oral; Polymerase Chain Reaction; Gene Expression Regulation, Enzymologic; Genotype; Heterozygote; Phenotype; Polymorphism, Genetic; Alleles; Asian Continental Ancestry Group; European Continental Ancestry Group; Proguanil; Cytochrome P-450 CYP2C19|
|Appears in Collections:||Pharmacology publications|
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