Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/14338
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Type: Journal article
Title: Association between CYP2C19 genotype and proguanil oxidative polymorphism.
Author: Coller, J.
Somogyi, A.
Bochner, F.
Citation: British Journal of Clinical Pharmacology, 1997; 43(6):659-660
Publisher: BLACKWELL SCIENCE LTD
Issue Date: 1997
ISSN: 0306-5251
1365-2125
Abstract: AIMS:To examine the relationship between proguanil metabolism and the number of mutations in CYP2C19 by comparing the CYP2C19 genotype and proguanil phenotype of 10 subjects. METHODS:Partial clearance and urinary metabolic ratio data were obtained from a previous study of 10 subjects [5]. Analysis of CYP2C19 genotypes was performed using PCR amplification followed by restriction endonuclease digestion of genomic DNA from a blood sample. RESULTS:The intrinsic partial clearance of PG to CG ranged from 0.41-10.11 h-1, and was related to the number of functional CYP2C19 alleles present. Genotypic PMs had metabolic ratios > 13, while genotypic heterozygote EMs had metabolic ratios < 9. CONCLUSIONS:Proguanil may be a suitable phenotyping probe for the CYP2C19 genetic polymorphism, however the exact antimode of the urinary metabolic ratio chosen to separate poor and extensive metabolisers needs further investigation.
Keywords: Humans; Cytochrome P-450 Enzyme System; Aryl Hydrocarbon Hydroxylases; DNA Restriction Enzymes; Mixed Function Oxygenases; DNA; Antimetabolites; Administration, Oral; Polymerase Chain Reaction; Gene Expression Regulation, Enzymologic; Genotype; Heterozygote; Phenotype; Polymorphism, Genetic; Alleles; Asian Continental Ancestry Group; European Continental Ancestry Group; Proguanil; Cytochrome P-450 CYP2C19
RMID: 0030003436
DOI: 10.1046/j.1365-2125.1997.00596.x
Appears in Collections:Pharmacology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.