Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/14338
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorColler, J.en
dc.contributor.authorSomogyi, A.en
dc.contributor.authorBochner, F.en
dc.date.issued1997en
dc.identifier.citationBritish Journal of Clinical Pharmacology, 1997; 43(6):659-660en
dc.identifier.issn0306-5251en
dc.identifier.issn1365-2125en
dc.identifier.urihttp://hdl.handle.net/2440/14338-
dc.description.abstractAIMS:To examine the relationship between proguanil metabolism and the number of mutations in CYP2C19 by comparing the CYP2C19 genotype and proguanil phenotype of 10 subjects. METHODS:Partial clearance and urinary metabolic ratio data were obtained from a previous study of 10 subjects [5]. Analysis of CYP2C19 genotypes was performed using PCR amplification followed by restriction endonuclease digestion of genomic DNA from a blood sample. RESULTS:The intrinsic partial clearance of PG to CG ranged from 0.41-10.11 h-1, and was related to the number of functional CYP2C19 alleles present. Genotypic PMs had metabolic ratios > 13, while genotypic heterozygote EMs had metabolic ratios < 9. CONCLUSIONS:Proguanil may be a suitable phenotyping probe for the CYP2C19 genetic polymorphism, however the exact antimode of the urinary metabolic ratio chosen to separate poor and extensive metabolisers needs further investigation.en
dc.language.isoenen
dc.publisherBLACKWELL SCIENCE LTDen
dc.subjectHumans; Cytochrome P-450 Enzyme System; Aryl Hydrocarbon Hydroxylases; DNA Restriction Enzymes; Mixed Function Oxygenases; DNA; Antimetabolites; Administration, Oral; Polymerase Chain Reaction; Gene Expression Regulation, Enzymologic; Genotype; Heterozygote; Phenotype; Polymorphism, Genetic; Alleles; Asian Continental Ancestry Group; European Continental Ancestry Group; Proguanil; Cytochrome P-450 CYP2C19en
dc.titleAssociation between CYP2C19 genotype and proguanil oxidative polymorphism.en
dc.typeJournal articleen
dc.identifier.rmid0030003436en
dc.identifier.doi10.1046/j.1365-2125.1997.00596.xen
dc.identifier.pubid67442-
pubs.library.collectionPharmacology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidColler, J. [0000-0002-8273-5048]en
dc.identifier.orcidSomogyi, A. [0000-0003-4779-0380]en
Appears in Collections:Pharmacology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.