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Type: Journal article
Title: A randomized, double-blind, placebo-controlled trial of pseudoephedrine in coryza
Author: Latte, G.
Taverner, D.
Slobodian, P.
Shakib, S.
Citation: Clinical and Experimental Pharmacology and Physiology, 2004; 31(7):429-432
Publisher: Blackwell Publishing Asia
Issue Date: 2004
ISSN: 0305-1870
Statement of
Latte, Jenny ; Taverner, David ; Slobodian, Peter ; Shakib, Sepehr
Abstract: 1. The aim of the present study was to assess the efficacy of pseudoephedrine in coryza. 2. In a double-blind, randomized, placebo-controlled design, 48 adults with acute coryza received a single oral dose of 60 mg pseudoephedrine (Sudafed; Pfizer Consumer HealthCare Group, Caringbah, NSW, Australia) or matching placebo. Before and after dosing, nasal airway resistance (NAR), nasal volume, the minimum intranasal cross-sectional area (MCA) and the symptom of nasal congestion were measured. 3. Pseudoephedrine produced a significant decrease in NAR (P = 0.005; 95% confidence interval (CI) 0.073, 0.383). Nasal volume increased, but this did not reach significance (P = 0.07; 95% CI -0.842, 0.034). There was no change in MCA and symptoms. 4. In conclusion, pseudoephedrine has a moderate effect in decreasing objective measures of nasal congestion in coryza.
Keywords: Humans; Nasal Obstruction; Ephedrine; Nasal Decongestants; Rhinometry, Acoustic; Double-Blind Method; Reproducibility of Results; Time Factors; Adolescent; Adult; Middle Aged; Female; Male
RMID: 0020040601
DOI: 10.1111/j.1440-1681.2004.04013.x
Appears in Collections:Pharmacology publications

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