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https://hdl.handle.net/2440/14359
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Type: | Journal article |
Title: | A randomized, double-blind, placebo-controlled trial of pseudoephedrine in coryza |
Author: | Latte, G. Taverner, D. Slobodian, P. Shakib, S. |
Citation: | Clinical and Experimental Pharmacology and Physiology, 2004; 31(7):429-432 |
Publisher: | Blackwell Publishing Asia |
Issue Date: | 2004 |
ISSN: | 0305-1870 1440-1681 |
Statement of Responsibility: | Latte, Jenny ; Taverner, David ; Slobodian, Peter ; Shakib, Sepehr |
Abstract: | 1. The aim of the present study was to assess the efficacy of pseudoephedrine in coryza. 2. In a double-blind, randomized, placebo-controlled design, 48 adults with acute coryza received a single oral dose of 60 mg pseudoephedrine (Sudafed; Pfizer Consumer HealthCare Group, Caringbah, NSW, Australia) or matching placebo. Before and after dosing, nasal airway resistance (NAR), nasal volume, the minimum intranasal cross-sectional area (MCA) and the symptom of nasal congestion were measured. 3. Pseudoephedrine produced a significant decrease in NAR (P = 0.005; 95% confidence interval (CI) 0.073, 0.383). Nasal volume increased, but this did not reach significance (P = 0.07; 95% CI -0.842, 0.034). There was no change in MCA and symptoms. 4. In conclusion, pseudoephedrine has a moderate effect in decreasing objective measures of nasal congestion in coryza. |
Keywords: | Humans Nasal Obstruction Ephedrine Nasal Decongestants Rhinometry, Acoustic Double-Blind Method Reproducibility of Results Time Factors Adolescent Adult Middle Aged Female Male |
DOI: | 10.1111/j.1440-1681.2004.04013.x |
Published version: | http://dx.doi.org/10.1111/j.1440-1681.2004.04013.x |
Appears in Collections: | Aurora harvest 7 Pharmacology publications |
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