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Type: Journal article
Title: Naloxone methiodide reverses opioid-induced respiratory depression and analgesia without withdrawal
Author: Lewanowitsch, T.
Irvine, R.
Citation: European Journal of Pharmacology, 2002; 445(1-2):61-67
Publisher: Elsevier Science BV
Issue Date: 2002
ISSN: 0014-2999
Statement of
Tanya Lewanowitsch and Rodney J. Irvine
Abstract: Illicit opioid overdoses are a significant problem throughout the world, with most deaths being attributed to opioid-induced respiratory depression which may involve peripheral mechanisms. The current treatment for overdoses is naloxone hydrochloride, which is effective but induces significant withdrawal. We propose that selectively peripherally acting opioid receptor antagonists, such as naloxone methiodide, could reverse respiratory depression without inducing predominantly centrally mediated withdrawal. Acute administration of morphine (300 mg/kg, i.p.) was found to significantly depress respiratory rate and induce analgesia (P<0.0001). Both naloxone hydrochloride and naloxone methiodide were able to reverse these effects but naloxone methiodide precipitated no significant withdrawal. Naloxone methiodide was also able to reverse opioid-induced respiratory depression (P<0.001) and antinociception (P<0.01) after chronic morphine administration (300 mg/kg/day for 5 days) without inducing significant withdrawal. Therefore, peripherally selective opioid receptor antagonists should be investigated as possible treatments for opioid-induced respiratory depression which do not induce adverse effects, such as withdrawal.
Keywords: Morphine; Naloxone; Naloxone methiodide; respiration; withdrawal
Description: Copyright © 2002 Elsevier Science B.V. All rights reserved.
RMID: 0020020638
DOI: 10.1016/S0014-2999(02)01715-6
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Appears in Collections:Pharmacology publications

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