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https://hdl.handle.net/2440/14441
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Type: | Journal article |
Title: | The cardiovascular protective role of docosahexaenoic acid. |
Author: | McLennan, P. Howe, P. Abeywardena, M. Muggli, R. Raederstorff, D. Mano, M. Rayner, T. Head, R. |
Citation: | European Journal of Pharmacology, 1996; 300(1-2):83-89 |
Publisher: | ELSEVIER |
Issue Date: | 1996 |
ISSN: | 0014-2999 1879-0712 |
Statement of Responsibility: | Peter McLennan, Peter Howe, Mahinda Abeywardena, Reto Muggli, Daniel Raederstorff, Mark Mano, Tim Rayner and Richard Head |
Abstract: | Dietary fish oils rich in n-3 polyunsaturated fatty acids can modulate a diverse range of factors contributing to cardiovascular disease. This study examined the relative roles of eicosapentaenoic acid (20:5 n-3; EPA) and docosahexaenoic acid (22:6 n-3; DHA) which are the principal n-3 polyunsaturated fatty acids regarded as candidates for cardioprotective actions. At low dietary intakes (0.4–1.1% of energy (%en)), docosahexaenoic acid but not eicosapentaenoic acid inhibited ischaemia-induced cardiac arrhythmias. At intakes of 3.9–10.0%en, docosahexaenoic acid was more effective than eicosapentaenoic acid at retarding hypertension development in spontaneously hypertensive rats (SHR) and inhibiting thromboxane-like vasoconstrictor responses in aortas from SHR. In stroke-prone SHR with established hypertension, docosahexaenoic acid (3.9–10.0%en) retarded the development of salt-loading induced proteinuria but eicosapentaenoic acid alone was ineffective. The results demonstrate that purified n-3 polyunsaturated fatty acids mimic the cardiovascular actions of fish oils and imply that docosahexaenoic acid may be the principal active component conferring cardiovascular protection. |
Keywords: | Dietary fat n-3 fatty acid Arrhythmia Blood pressure Proteinuria Thromboxane |
Rights: | © 1996 Elsevier Science B.V |
DOI: | 10.1016/0014-2999(95)00861-6 |
Published version: | http://www.sciencedirect.com.proxy.library.adelaide.edu.au/science/article/pii/0014299995008616# |
Appears in Collections: | Aurora harvest 7 Pharmacology publications |
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