Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/14453
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Inhibition of low-density lipoprotein oxidation and up-regulation of low-density lipoprotein receptor in HepG2 cells by tropical plant extracts |
Author: | Salleh, Mohammed Nizar Runnie, Irine Roach, Paul D. Mohamed, Suhaila Abeywardena, Mahinda Y. |
Citation: | Journal of Agricultural and Food Chemistry, 2002; 50(13):3693-3697 |
Publisher: | American Chemical Society |
Issue Date: | 2002 |
ISSN: | 0021-8561 |
Statement of Responsibility: | Mohd. Nizar Salleh, Irine Runnie, Paul D. Roach, Suhaila Mohamed and Mahinda Y. Abeywardena |
Abstract: | Twelve edible plant extracts rich in polyphenols were screened for their potential to inhibit oxidation of low-density lipoprotein (LDL) in vitro and to modulate LDL receptor (LDLr) activity in cultured HepG2 cells. The antioxidant activity (inhibition of LDL oxidation) was determined by measuring the formation of conjugated dienes (lag time) and thiobarbituric acid reagent substances (TBARS). Betel leaf (94%), cashew shoot (63%), Japanese mint (52%), semambu leaf (50%), palm frond (41%), sweet potato shoot, chilli fruit, papaya shoot, roselle calyx, and maman showed significantly increased lag time (>55 min, P < 0.05) and inhibition of TBARS formation (P < 0.05) compared to control. LDLr was significantly up-regulated (P < 0.05) by Japanese mint (67%), semambu (51%), cashew (50%), and noni (49%). Except for noni and betel leaf, most plant extracts studied demonstrated a positive association between antioxidant activity and the ability to up-regulate LDL receptor. Findings suggest that reported protective actions of plant polyphenols on lipoprotein metabolism might be exerted at different biochemical mechanisms. |
Keywords: | LDL oxidation ; LDL receptor ; plant extracts ; TBARS ; HepG2 cells |
Rights: | Copyright © 2002 American Chemical Society |
DOI: | 10.1021/jf011593f |
Appears in Collections: | Pharmacology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.