Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/14468
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDyer, K.en
dc.contributor.authorWhite, J.en
dc.contributor.authorFoster, D.en
dc.contributor.authorBochner, F.en
dc.contributor.authorMenelaou, A.en
dc.contributor.authorSomogyi, A.en
dc.date.issued2001en
dc.identifier.citationJournal of Clinical Psychopharmacology, 2001; 21(1):78-84en
dc.identifier.issn0271-0749en
dc.identifier.issn1533-712Xen
dc.identifier.urihttp://hdl.handle.net/2440/14468-
dc.description.abstractAlthough methadone maintenance is designed to stabilize opioid-dependent patients, some experience significant withdrawal in the latter part of the 24-hour interdosing interval. This study was designed to determine the mood changes that maybe associated with such withdrawal. Eighteen methadone patients, nine of whom experienced significant withdrawal, were tested over a single interdosing interval. During this time, 13 blood samples were collected to measure plasma racemic methadone concentrations, and the Profile of Mood States (POMS) was administered on 11 of these occasions. The POMS was also administered on 11 occasions over 24 hours to 10 drug-free healthy controls. In comparison with controls, methadone patients showed increased anger, depression, tension, confusion, and fatigue, as well as decreased vigor. For all scales, maximal differences from controls occurred at times of trough methadone concentration and minimal differences around the time of peak concentration. Changes in mood over the interdosing interval were more exaggerated in the nine patients who experienced significant withdrawal compared with those who did not. The composite Total Mood Disturbance (TMD) scores were calculated for each subject at each time point. The sigmoid Emax model was used to relate plasma concentrations to these data and to calculate the slope factor (N). This model could be fitted for 14 of the 18 patients with a mean +/- SEM slope factor of 2.2 +/- 0.5. TMD score was also shown to be inversely related to the rate of decline in methadone concentration from peak to trough. These results show that significant mood changes occur in response to changes in methadone concentration, and these are more pronounced in those who experience withdrawal. The concentration-effect relationships suggest that relatively small changes in plasma concentration will result in significant mood change. Differences in the degree of mood change between those who do and do not experience significant withdrawal may be explained by variation in the rate of decline in plasma concentration from peak to trough.en
dc.description.statementofresponsibilityKyle R. Dyer, Jason M. White, David J.R. Foster, Felix Bochner, Andrew Menelaou, and Andrew A. Somogyien
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.rights© 2001 Lippincott Williams & Wilkins, Inc.en
dc.subjectHumans; Opioid-Related Disorders; Substance Withdrawal Syndrome; Methadone; Analgesics, Opioid; Affect; Adult; Middle Aged; Female; Maleen
dc.titleThe relationship between mood state and plasma methadone concentration in maintenance patientsen
dc.typeJournal articleen
dc.identifier.rmid0020010776en
dc.identifier.doi10.1097/00004714-200102000-00014en
dc.identifier.pubid61800-
pubs.library.collectionPharmacology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidFoster, D. [0000-0002-7345-4084]en
dc.identifier.orcidSomogyi, A. [0000-0003-4779-0380]en
Appears in Collections:Pharmacology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.