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https://hdl.handle.net/2440/14480
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Type: | Journal article |
Title: | Absorption of morphine from a slow-release emulsion used to induce morphine dependence in rats. |
Author: | Salem, A. Hope, W. |
Citation: | Journal of Pharmacological and Toxicological Methods, 1999; 40(3):159-164 |
Publisher: | ELSEVIER SCIENCE INC |
Issue Date: | 1999 |
ISSN: | 1056-8719 1873-488X |
Abstract: | This study was performed to measure absorption of morphine from the injection site following treatment of rats with slow-release emulsions formulated with morphine hydrochloride and morphine base. Samples of emulsion were collected from the injection site of halothane anesthetized animals at 24 and 48 h following emulsion treatment and concentrations of morphine remaining in the emulsion were analyzed using high-performance liquid chromatography (HPLC). In another group of morphine-treated rats, at times equivalent to collecting samples of emulsion, the intensity of naloxone-precipitated withdrawal behaviors was monitored. Both morphine base- and hydrochloride-containing emulsions induced a high degree of physical dependence in animals treated over 48 h. Release of morphine from emulsions containing morphine base was slower than that from the hydrochloride formulations. In the 24-h morphine base-treated animals, approximately 45% was absorbed from the injection site as opposed to 99% in the 24-h morphine hydrochloride-treated animals. These results suggest that morphine base containing emulsions provide a more sustained exposure to the opioid. |
Keywords: | Feces Animals Rats Rats, Wistar Morphine Dependence Body Weight Morphine Emulsions Delayed-Action Preparations Chromatography, High Pressure Liquid Administration, Cutaneous Female |
DOI: | 10.1016/S1056-8719(98)00050-1 |
Published version: | http://dx.doi.org/10.1016/s1056-8719(98)00050-1 |
Appears in Collections: | Aurora harvest 2 Pharmacology publications |
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