Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/14495
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Type: Journal article
Title: The relationship between blood benzodiazepine concentration and vehicle crash culpability
Author: Longo, Maria C.
Lokan, Robert J.
White, Jason Mark
Citation: Journal of Traffic Medicine: an international journal of traffic safety, 2001; 29:36-43
Publisher: International Association for Accident and Traffic Medicine
Issue Date: 2001
ISSN: 0345-5564
School/Discipline: School of Medical Sciences : Pharmacology
School of Medical Sciences : Pharmacology
Statement of
Responsibility: 
Marie C. Longo, Robert J. Lokan and Jason M. White
Abstract: OBJECTIVE: The purpose of this study was to determine the relationship between blood benzodiazepine concentration and crash risk. METHODS: Blood samples from 2500 injured drivers were analyzed for benzodiazepines and the relationship between concentration and crash risk was assessed using culpability analysis. Benzodiazepine concentrations were expressed as a proportion of the peak concentration of the drug in blood or plasma for a standard therapeutic dose of the drug. RESULTS: There were 68 drivers (2.7%) who tested positive for at least one benzodiazepine. Of these, 16 (23.5%) also tested positive for alcohol. Drivers who tested positive for benzodiazepines, either alone or in combination with alcohol, had a higher culpability rate than drug-free drivers. There was a significant linear relationship between benzodiazepine concentration and culpability for drivers who tested positive for benzodiazepines alone. CONCLUSION: The results here provide clear evidence of increased culpability associated with benzodiazepine use, which was marked at higher concentrations.
Description: © International Association for Accident and Traffic Medicine
RMID: 0020011481
DOI: 10.1016/j.jflm.2008.04.002
Appears in Collections:Pharmacology publications

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