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|Title:||The relationship between blood benzodiazepine concentration and vehicle crash culpability|
|Author:||Longo, Maria C.|
Lokan, Robert J.
White, Jason Mark
|Citation:||Journal of Traffic Medicine: an international journal of traffic safety, 2001; 29:36-43|
|Publisher:||International Association for Accident and Traffic Medicine|
|School/Discipline:||School of Medical Sciences : Pharmacology|
School of Medical Sciences : Pharmacology
|Marie C. Longo, Robert J. Lokan and Jason M. White|
|Abstract:||OBJECTIVE: The purpose of this study was to determine the relationship between blood benzodiazepine concentration and crash risk. METHODS: Blood samples from 2500 injured drivers were analyzed for benzodiazepines and the relationship between concentration and crash risk was assessed using culpability analysis. Benzodiazepine concentrations were expressed as a proportion of the peak concentration of the drug in blood or plasma for a standard therapeutic dose of the drug. RESULTS: There were 68 drivers (2.7%) who tested positive for at least one benzodiazepine. Of these, 16 (23.5%) also tested positive for alcohol. Drivers who tested positive for benzodiazepines, either alone or in combination with alcohol, had a higher culpability rate than drug-free drivers. There was a significant linear relationship between benzodiazepine concentration and culpability for drivers who tested positive for benzodiazepines alone. CONCLUSION: The results here provide clear evidence of increased culpability associated with benzodiazepine use, which was marked at higher concentrations.|
|Description:||© International Association for Accident and Traffic Medicine|
|Appears in Collections:||Pharmacology publications|
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