Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/14572
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Type: Journal article
Title: Assessment of interlaboratory performance in the provision of perhexiline therapeutic drug monitoring services in Australia.
Author: Sallustio, B.
Morris, R.
Citation: Therapeutic Drug Monitoring, 1999; 21(4):389-394
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Issue Date: 1999
ISSN: 0163-4356
1536-3694
Abstract: Perhexiline is a prophylactic antianginal agent particularly useful in patients whose angina is poorly controlled or refractory to conventional drug regimens. Although perhexiline can cause serious hepatic and neurological toxicity, maintaining trough plasma concentrations between 0.15-0.60 mg/L minimizes the risk of toxicity while providing relief of angina symptoms in a majority of patients. All pathology laboratories are required to participate in interlaboratory proficiency testing (PT) programs. The authors therefore initiated a monthly PT program to assess the performance of Australian laboratories measuring perhexiline (n = 8). PT specimens included perhexiline-spiked drug-free human plasma and pooled plasma from patients administered perhexiline. The performance of 8 Australian laboratories participating in the program was examined over a 30-month period. The mean relative standard deviation of the group was 18.2%. All centers performed well with respect to accuracy, achieving mean percentage bias within +/-8% of target perhexiline concentrations. The usefulness of the PT program was highlighted by the identification of two laboratories with an unacceptable degree of variability (up to 30% of results varied more than +/-55% from the target concentration), and the identification of potential analytical problems with the use of perhexiline metabolite concentrations for determining patients' hydroxylator status. Continued and improved use of PT by pathology laboratories is essential to ensuring the safe and effective clinical use of perhexiline.
Keywords: Humans; Angina Pectoris; Perhexiline; Cardiovascular Agents; Drug Monitoring; Chromatography, Gas; Chromatography, High Pressure Liquid; Reproducibility of Results; Quality Control; Laboratories; Australia
RMID: 0030003370
DOI: 10.1097/00007691-199908000-00002
Appears in Collections:Pharmacology publications

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