Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/14587
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Type: Journal article
Title: Isolation and toxicity of cylindrospermopsis raciborskii from an ornamental lake.
Author: Hawkins, P.
Chandrasena, H.
Jones, G.
Humpage, A.
Falconer, I.
Citation: Toxicon, 1997; 35(3):341-346
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Issue Date: 1997
ISSN: 0041-0101
1879-3150
Abstract: In Australia, the tropical/subtropical cyanobacterium Cylindrospermopsis raciborskii forms substantial blooms in some drinking water supply reservoirs, rivers and recreational water bodies during the warmer months of the year. This paper describes the isolation, culture and toxicity characterisation of Cylindrospermopsis from a water bloom in a small lake in NSW, Australia. The cyanobacterium grew as straight trichomes terminating with a characteristic heterocyst. The toxic alkaloid cylindrospermopsin was separated and identified by high-performance liquid chromatography at a concentration of 5.5 mg/g dry cells, 0.026 pg/cell. Intraperitoneal injection of sonicated cells caused liver, kidney, intestinal and lung damage, with an LD50 of 52 mg cells/kg mouse body weight at 24 hr, and 32 mg/kg at 7 days. The 24 hr mouse toxicity is not consistent with previous studies using pure cylindrospermopsin, and is suggestive of other toxic compounds in this isolate.
Keywords: Animals; Mice; Cyanobacteria; Alkaloids; Chromatography, High Pressure Liquid; Injections, Intraperitoneal; Lethal Dose 50; Fresh Water; Male
RMID: 0030003367
DOI: 10.1016/S0041-0101(96)00185-7
Appears in Collections:Pharmacology publications
Environment Institute publications

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