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Type: Journal article
Title: Cardiovascular and haemodynamic effects of intramuscular doses of xylazine in conscious sheep
Author: Grant, C.
Upton, R.
Citation: Australian Veterinary Journal, 2001; 79(1):58-60
Publisher: Australian Veterinary Assn
Issue Date: 2001
ISSN: 0005-0423
Abstract: OBJECTIVE: To determine if a commonly used analgesic dose of xylazine has detrimental cardiovascular or haemodynamic effects in sheep. DESIGN: A physiological study following intramuscular administration of xylazine. PROCEDURE: Xylazine (50 micrograms/kg) was injected intramuscularly into six healthy Merino ewes. For 60 min heart rate, mean arterial blood pressure and cardiac output were recorded; arterial blood samples for the measurement of blood gas tensions were also collected. RESULTS: There were no significant changes in heart rate, mean arterial blood pressure, cardiac output or arterial carbon dioxide tension. A slight degree of arterial hypoxaemia was noted with a 10% reduction in arterial oxygen tension values at 30 min. CONCLUSION: The minimal changes to cardiovascular and respiratory values in this study verify the safety of previously suggested analgesic dosing regimens for sheep. Previously reported hypoxaemic effects in sheep as a result of intravenous xylazine administration appear to be reduced as a result of intramuscular administration.
Keywords: Sheep; analgesia; xylazine; hypoxaemia
RMID: 0020010725
DOI: 10.1111/j.1751-0813.2001.tb10642.x
Appears in Collections:Anaesthesia and Intensive Care publications

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