Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/14751
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Type: Journal article
Title: A xylazine infusion regimen to provide analgesia in sheep
Author: Grant, C.
Summersides, G.
Kuchel, T.
Citation: Laboratory Animals, 2001; 35(3):277-281
Publisher: Royal Soc Medicine Press Ltd
Issue Date: 2001
ISSN: 0023-6772
1758-1117
Abstract: The efficacy of continuous low-dose xylazine infusion following an initial loading dose in providing analgesia in sheep was examined using an algesimetry method based on a leg lifting response to an electrical stimulus. Sheep received a 5 mg intramuscular injection of xylazine followed by continuous infusion of intravenous xylazine (2 mg/h) for 90 min. This treatment resulted in significant increases in the level of current required to elicit a leg lifting response (287% of baseline) and steady state analgesia was maintained from 10 min after the start of the infusion until the end of the experimental period. This protocol appears to be a simple and effective regimen for providing steady state analgesia in sheep.
Keywords: Animals; Sheep; Xylazine; Adrenergic alpha-Agonists; Analgesia; Injections, Intramuscular; Male
RMID: 0020010733
DOI: 10.1258/0023677011911606
Appears in Collections:Anaesthesia and Intensive Care publications

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