Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/16795
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dc.contributor.authorOng, J.en
dc.contributor.authorParker, D.en
dc.contributor.authorMarino, V.en
dc.contributor.authorKerr, D.en
dc.contributor.authorPuspawati, N.en
dc.contributor.authorPrager, R.en
dc.date.issued2005en
dc.identifier.citationEuropean Journal of Pharmacology, 2005; 507(1-3):35-42en
dc.identifier.issn0014-2999en
dc.identifier.issn1879-0712en
dc.identifier.urihttp://hdl.handle.net/2440/16795-
dc.description.abstractUsing grease-gap recording from rat neocortical slices, the GABA(B) receptor agonist baclofen elicited reversible and concentration-dependent hyperpolarizing responses (EC50=18+/-2.3 microM). The hyperpolarizations were antagonised by the GABA(B) receptor antagonist Sch 50911 [(+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid). (+)-N-1-(3-chloro-4-methoxyphenyl)ethyl-3,3-diphenylpropylamine (3-chloro,4-methoxyfendiline; 3-Cl,4-MeO-fendiline) reversibly potentiated baclofen-induced hyperpolarizing responses, which were reduced by Sch 50911, producing leftward shifts of the baclofen concentration-response curves, with a marked increase in the maximal hyperpolarization (EC50=2+/-0.5 microM). In slices preincubated with either [3H]GABA or [3H]glutamic acid, 3-Cl,4-MeO-fendiline (1 microM) potentiated the inhibitory effect of baclofen (2 microM) on the electrically evoked release of [3H]GABA and had a similar effect on the release of [3H]glutamic acid at a concentration of 0.5 microM, without affecting the basal release. These effects were blocked by Sch 50911 (10 microM). Our findings suggest that 3-Cl,4-MeO-fendiline is a potent potentiator of pre- and postsynaptic GABA(B) receptor-mediated functions.en
dc.language.isoenen
dc.publisherElsevier Science BVen
dc.subjectNeocortex; Baclofen; 3-Chloro,4-methoxyfendiline; Pre- and postsynaptic GABAB receptor; (Rat)en
dc.title3-Chloro,4-methoxyfendiline is a potent GABAB receptor potentiator in rat neocortical slicesen
dc.typeJournal articleen
dc.identifier.rmid0020051265en
dc.identifier.doi10.1016/j.ejphar.2004.11.029en
dc.identifier.pubid54464-
pubs.library.collectionDentistry publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Dentistry publications

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