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https://hdl.handle.net/2440/16951
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Type: | Journal article |
Title: | Dietary nucleotides do not alter erythrocyte long-chain polyunsaturated fatty acids in formula-fed term infants |
Author: | Gibson, R. Hawkes, J. Makrides, M. |
Citation: | Lipids, 2005; 40(6):631-634 |
Publisher: | Amer Oil Chemists Soc A O C S Press |
Issue Date: | 2005 |
ISSN: | 0024-4201 1558-9307 |
Statement of Responsibility: | Robert A. Gibson, Joanna S. Hawkes and Maria Makrides |
Abstract: | There have been conflicting reports regarding the effectiveness of dietary nucleotides (NT) to regulate tissue desaturases and hence stimulate accumulation of both n-6 and n-3 long-chain polyunsaturated fatty acids (LCPUFA). The aim of this study was to examine the effect of NT-supplemented cow’s milkbased formula on erythrocyte phospholipid FA status in a large randomized controlled trial involving a well-nourished infant population born at term. Formula-fed infants were allocated to control formula with an innate level of NT at 10 mg/L (n = 102), or formula fortified with NT at 34 mg/L (n = 98). A parallel group of breastfed infants was included as a reference. Peripheral blood samples were collected by venipuncture at 7 mon of age and erythrocyte phospholipid FA determined by capillary GC. Erythrocyte LCPUFA levels did not differ between the NT-supplemented and control formula groups and were reduced in both groups compared with breastfed infants. We conclude that there is no induction of LCPUFA accumulation in erythrocyte phospholipids of term, formula-fed infants following 7 mon of NT supplementation. |
Keywords: | Erythrocytes Humans Nucleotides Fatty Acids, Unsaturated Phospholipids Breast Feeding Gestational Age Infant Formula Infant Food Infant Infant, Newborn |
DOI: | 10.1007/s11745-005-1425-x |
Published version: | http://dx.doi.org/10.1007/s11745-005-1425-x |
Appears in Collections: | Agriculture, Food and Wine publications Aurora harvest 2 |
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